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Melatonin for prevention of metabolic side-effects of olanzapine in patients with first-episode schizophrenia: randomized double-blind placebo-controlled study.
Author: AshrafiMandana, HeidariParvaneh, ModabberniaAmirhossein, ModabberniaMohammad Jafar, RoshanZahra Atrkar, SobhaniAbdolrasoul, SoleimaniRobabeh, TaslimiShervin
Original Abstract of the Article :
We aimed to determine the efficacy of melatonin 3 mg/day in prevention of olanzapine-induced metabolic side-effects. In a randomized double-blind placebo-controlled study, 48 patients with first-episode schizophrenia who were eligible for olanzapine treatment, were randomly assigned to olanzapine pl...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.jpsychires.2014.02.013
データ提供:米国国立医学図書館(NLM)
Melatonin: A Potential Oasis in the Desert of Olanzapine Side Effects
The desert of medicine is full of challenges, and treating mental health conditions like schizophrenia is no exception. Olanzapine, a commonly used antipsychotic medication, can have metabolic side effects, like a desert traveler facing dehydration. This study investigated the potential of melatonin, a naturally occurring hormone, to mitigate these side effects.
The researchers, like desert explorers seeking a safe path through a challenging landscape, conducted a randomized controlled trial. They compared the effects of olanzapine alone with olanzapine combined with melatonin. The results showed that melatonin significantly reduced weight gain, waist circumference increase, and triglyceride levels, suggesting that it might be a valuable tool in mitigating the metabolic side effects of olanzapine.
A New Oasis in the Desert of Metabolic Side Effects
The study suggests that melatonin could be a valuable tool in mitigating the metabolic side effects of olanzapine. It provides a beacon of hope for patients who are concerned about these side effects.
Navigating the Desert of Antipsychotic Treatment
The study underscores the importance of personalized treatment approaches for patients with schizophrenia. The findings suggest that melatonin could be a valuable addition to treatment regimens, helping patients manage the metabolic side effects of antipsychotics.
Dr.Camel's Conclusion
This study highlights the potential of melatonin to mitigate the metabolic side effects of olanzapine. It's a reminder that even in the challenging desert of mental health treatment, we can find oases of hope and better treatment strategies.
Date :
- Date Completed 2014-11-24
- Date Revised 2018-12-02
Further Info :
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