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Febrile pleuropericarditis, a potentially life-threatening adverse event of balsalazide--case report and literature review of the side effects of 5-aminosalicylates.

Author: ComanRoxana M, GjymishkaAltin, GloverSarah C

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Ulcerative colitis (UC) is a chronic inflammatory bowel disease. While 5-aminosalicylates (5-ASAs) are effective treatments for UC, they can cause rare but potentially serious side effects, including inflammation of the heart and lungs. This report describes a case of pericarditis and pleuropericarditis in a patient taking balsalazide, a 5-ASA drug.
Paper Details　
Original Abstract of the Article :
Ulcerative colitis (UC) is an idiopathic chronic inflammatory disorder that affects the colonic mucosa. One class among the drugs used for its treatment is the 5-aminosalicylates (5-ASAs). While highly efficacious in treating mild-to-moderate UC, 5-ASAs are associated with rare but potentially life-...See full text at original site
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引用元：
https://doi.org/10.1586/1744666X.2014.902313

データ提供：米国国立医学図書館（NLM）

Balsalazide: A Cautionary Tale of Rare but Serious Side Effects

This case report highlights the potential for [febrile pleuropericarditis], a rare but potentially life-threatening adverse event, to occur in patients treated with [balsalazide], a 5-aminosalicylate (5-ASA) drug used to treat ulcerative colitis. The authors provide a comprehensive review of the known side effects of 5-ASAs, emphasizing the importance of early recognition and prompt management of these rare but serious adverse events. This study underscores the need for vigilant monitoring and careful assessment in patients receiving 5-ASA therapy.

The Importance of Vigilance in 5-ASA Therapy

The study underscores the importance of vigilant monitoring and careful assessment in patients receiving 5-ASA therapy, particularly those with ulcerative colitis. The authors highlight the potential for rare but serious adverse events, including febrile pleuropericarditis, to occur. This study encourages a proactive approach to managing 5-ASA therapy, emphasizing the need for prompt recognition and management of any potential adverse events to ensure patient safety and optimize treatment outcomes.

Navigating the Landscape of 5-ASA Therapy

The study highlights the potential for rare but serious adverse events, including febrile pleuropericarditis, to occur in patients receiving 5-ASA therapy. This study encourages a proactive approach to managing 5-ASA therapy, emphasizing the need for prompt recognition and management of any potential adverse events to ensure patient safety and optimize treatment outcomes.

Dr.Camel's Conclusion

This research reminds us that even in the vast desert of ulcerative colitis treatment, where we seek to alleviate suffering and improve quality of life, there are always hidden dangers to be aware of. The authors emphasize the importance of vigilance and careful assessment in patients receiving 5-ASA therapy, reminding us to always be prepared for the unexpected. This study encourages continued exploration of the safety profile of 5-ASAs, seeking to optimize treatment strategies and ensure the best possible outcomes for patients with ulcerative colitis.

Date :
  1. Date Completed 2014-12-15
  2. Date Revised 2014-04-16
Further Info :

Pubmed ID

24689504

DOI: Digital Object Identifier

10.1586/1744666X.2014.902313

Related Literature

Article Analysis
・Side Effects of balsalazide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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