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Telaprevir with peginterferon/ribavirin for retreatment of null responders with advanced fibrosis post-orthotopic liver transplant.

Author: FridellJonathan A, GhabrilMarwan, Joseph TectorAlfred, KwoPaul Y, LacerdaMarco A, ViannaRodrigo

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Telaprevir added to peginterferon/ribavirin led to significant clearance rates in null responders to peginterferon/ribavirin with advanced fibrosis post-orthotopic liver transplant (OLT).
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Aggressive recurrence of hepatitis C remains problematic post-orthotopic liver transplant (OLT). There are limited data on treatment of HCV infection with telaprevir/boceprevir therapy with peginterferon/ribavirin (PR) post-OLT. AIM: To review our experience with telaprevir addition t...See full text at original site
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引用元：
https://doi.org/10.1111/ctr.12372

データ提供：米国国立医学図書館（NLM）

Telaprevir for Hepatitis C Retreatment: A Complex Challenge

This study examines the use of telaprevir in combination with peginterferon/ribavirin (PR) for the retreatment of hepatitis C in patients who had previously failed PR therapy. The study focuses on patients with advanced fibrosis who have undergone orthotopic liver transplant (OLT). The findings suggest that telaprevir can lead to significant clearance rates, but patients may experience high rates of anemia and require frequent dose adjustments.

Telaprevir - A Promising Treatment for Hepatitis C

The study demonstrates the potential of telaprevir as a retreatment option for hepatitis C in null responders with advanced fibrosis. The authors found that telaprevir achieved significant clearance rates at week 24, indicating its ability to combat the virus even in challenging cases. However, the study also highlights the need to monitor for potential side effects and adjust treatment accordingly.

Managing Complications: Hepatitis C and the Importance of Monitoring

This research sheds light on the complexities of treating hepatitis C, particularly in post-OLT patients with advanced fibrosis. The study highlights the need for careful monitoring to manage potential side effects and ensure optimal treatment outcomes. It underscores the importance of tailoring treatment strategies to individual patient needs and the importance of ongoing research in this field.

Dr. Camel's Conclusion

Just as a camel adapts to survive in the desert, hepatitis C patients must adapt to their treatment regimens. This research demonstrates the potential of telaprevir as a valuable tool in the fight against hepatitis C, but also highlights the need for careful management of potential complications. The journey to conquer hepatitis C remains ongoing, but this study provides valuable insights into improving patient outcomes and navigating the complexities of this chronic disease.
Date :
  1. Date Completed 2015-02-04
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24708229

DOI: Digital Object Identifier

10.1111/ctr.12372

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Languages

English

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