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Automated analysis of delayed emesis in the telemetered ferret: detection of synergistic effects of aprepitant and ondansetron.

Author: BarraisLaurence, CastagnéVincent, GoineauSonia, GuillaumePhilippe

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the sensitivity of an automated emesis model in ferrets for detecting the effects of antiemetics. The model effectively detected the synergistic effects of aprepitant and ondansetron in reducing cisplatin-induced delayed emesis, highlighting its potential for evaluating combination therapies for chemotherapy-induced nausea and vomiting.
Paper Details　
Original Abstract of the Article :
Nausea and vomiting are common side effects of cancer chemotherapy. We have previously described a model in the ferret where delayed emesis can be measured automatically using telemetry. This study was designed to examine the sensitivity of this automated emesis model for detecting moderate and/or a...See full text at original site
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引用元：
https://doi.org/10.1111/fcp.12082

データ提供：米国国立医学図書館（NLM）

Automated Analysis of Delayed Emesis: Unveiling Synergistic Effects in Cancer Chemotherapy

Nausea and vomiting are common side effects of cancer chemotherapy, significantly impacting patients' quality of life. This research investigates the synergistic effects of aprepitant and ondansetron, two antiemetic medications, on delayed-phase emesis in a telemetered ferret model. The authors utilized an automated system to measure emetic episodes, demonstrating that the combined treatment significantly reduced the number of emetic events compared to either medication alone. Their findings suggest that combining aprepitant and ondansetron may enhance antiemetic efficacy.

Combating Chemotherapy-Induced Emesis: A Collaborative Approach

The desert of cancer treatment can be harsh, often accompanied by the unwelcome side effect of nausea and vomiting. This research sheds light on a collaborative approach to combat this challenge, demonstrating the potential of combining aprepitant and ondansetron to minimize emetic episodes.

Managing Chemotherapy Side Effects: A Holistic Approach

Cancer treatment is a journey that requires a multidisciplinary approach. This research highlights the importance of managing side effects, such as nausea and vomiting, to ensure a better quality of life for patients undergoing chemotherapy. It underscores the role of medications and individualized treatment plans in providing relief and improving overall well-being.

Dr.Camel's Conclusion

The desert of cancer treatment can be a challenging terrain, but this research offers a glimpse of a potential oasis of relief. By understanding the synergistic effects of aprepitant and ondansetron, we can work towards minimizing the discomfort of chemotherapy-induced emesis and enhance the overall quality of life for patients. It's a reminder that even in the face of difficult challenges, advancements in medicine can pave the way for a brighter future.

Date :
  1. Date Completed 2015-07-15
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24750138

DOI: Digital Object Identifier

10.1111/fcp.12082

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・Effects of aprepitant
SNS
PICO Info
in preparation
Languages

English

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