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Pharmacokinetics, pharmacodynamics, and safety of pasireotide LAR in patients with acromegaly: a randomized, multicenter, open-label, phase I study.
Author: ArafatAyman M, BeckersAlbert, BollerslevJens, GiannoneVanessa, HuKe, HughesGareth, KatznelsonLaurence, LasherJanet, PetersennStephan, ReséndizKarina Hermosillo, SchopohlJochen, SerriOmar, ShenGeorge
Original Abstract of the Article :
Pasireotide (SOM230), a multireceptor-targeted somatostatin analogue, has exhibited favorable safety/tolerability in several clinical studies. A long-acting-release (LAR) formulation of pasireotide may offer advantages over the subcutaneous formulation. This randomized, open-label, Phase I study eva...See full text at original site
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引用元:
https://doi.org/10.1002/jcph.326
データ提供:米国国立医学図書館(NLM)
Pasireotide LAR: A New Hope for Acromegaly Treatment
Imagine a condition where your body produces excessive growth hormone, leading to various physical changes. This study delved into the potential of pasireotide LAR, a long-acting formulation of a drug that helps to regulate growth hormone levels. The researchers conducted a randomized, open-label, Phase I study to assess the safety, pharmacokinetic properties, and effectiveness of pasireotide LAR in patients with acromegaly. The study aimed to explore the potential of this new formulation to provide a more convenient and effective treatment for this condition.
Pasireotide LAR: Safety, Effectiveness, and Convenience
The study found that pasireotide LAR was generally well tolerated and achieved steady-state pharmacokinetics after three monthly doses. It effectively controlled growth hormone levels and improved symptoms of acromegaly. The findings suggest that pasireotide LAR may offer a more convenient treatment option, requiring less frequent administration compared to other formulations.
Understanding the Implications for Acromegaly Management
This study sheds light on a potentially promising treatment for acromegaly. The findings suggest that pasireotide LAR may offer a more convenient and effective treatment option, improving the quality of life for patients. As always, more research is needed to further evaluate the long-term benefits and potential side effects of this medication. It's important to have a thorough discussion with your healthcare provider to determine if pasireotide LAR is the right treatment for you.
Dr.Camel's Conclusion
This study is a reminder that innovation is constantly happening in the world of medicine, much like the endless cycle of change in the desert. Pasireotide LAR shows promise as a new treatment option for acromegaly, potentially improving the lives of patients with this condition. It's a testament to the dedication of researchers to find new ways to address challenging medical conditions.
Date :
- Date Completed 2015-10-13
- Date Revised 2022-03-09
Further Info :
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