Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors.

Author: BraunDoreen, BrietClaire, IllouzFrédéric, RodienPatrice, SchweizerUlrich

Paper Details 
Original Abstract of the Article :
Tyrosine kinase inhibitors (TKIs) are currently used by most oncologists. Among their side effects, thyroid dysfunctions are nowadays clearly observed. Whereas changes in thyroid function tests have been originally described with sunitinib, we now know that many TKIs can induce hypothyroidism and hy...See full text at original site
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引用元:
https://doi.org/10.1530/EJE-14-0198

データ提供:米国国立医学図書館(NLM)

The Effect of Tyrosine Kinase Inhibitors on Thyroid Function

In the realm of oncology, tyrosine kinase inhibitors (TKIs) have become a mainstay in treating various cancers. However, these drugs can sometimes have unintended consequences, including thyroid dysfunction. This research delves into the complex relationship between TKIs and thyroid health, shedding light on the mechanisms behind these side effects. The authors examined the different TKI molecules implicated in thyroid dysfunction and analyzed the latest data on the physiological mechanisms involved. Their goal was to propose a strategic approach for monitoring thyroid function in patients undergoing TKI therapy. They discovered that TKIs can induce both hypothyroidism and hyperthyroidism, a finding that has significant implications for patient care.

TKIs: A Double-Edged Sword

The study reveals a double-edged sword when it comes to TKIs. While these drugs are effective in battling cancer, they can disrupt thyroid function, creating a delicate balance between treating the disease and managing potential side effects. This study highlights the importance of careful monitoring of thyroid function in patients undergoing TKI therapy. The findings provide valuable insights into the potential complications of these medications and emphasize the need for personalized treatment strategies.

Thyroid Health: A Crucial Factor

This research emphasizes the critical role of thyroid health in overall well-being. The study’s findings underscore the need for a comprehensive approach to cancer treatment, taking into account not only the tumor but also the potential impact on other vital organs, such as the thyroid. This research serves as a reminder that maintaining thyroid health is essential, particularly when undergoing treatments that can affect its function.

Dr.Camel's Conclusion

Just like the desert holds both beautiful oases and treacherous sandstorms, TKIs offer both powerful cancer-fighting properties and potential side effects. This research sheds light on one of these side effects, thyroid dysfunction, and emphasizes the importance of careful monitoring and personalized treatment strategies.
Date :
  1. Date Completed 2014-09-22
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

24833135

DOI: Digital Object Identifier

10.1530/EJE-14-0198

Related Literature

SNS
PICO Info
in preparation
Languages

English

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