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CB1 cannabinoid receptors are involved in neuroleptic-induced enhancement of brain neurotensin.

Author: HassanzadehParichehr, RostamiFatemeh

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Neurotensin is a neuropeptide that is involved in the mechanism of action of antipsychotics. This study investigated the effects of fluphenazine and amisulpride, two antipsychotic drugs, on brain regional contents of neurotensin.
Paper Details　
Original Abstract of the Article :
Objective(s ): Targeting the neuropeptide systems has been shown to be useful for the development of more effective antipsychotic drugs. Neurotensin, an endogenous neuropeptide, appears to be involved in the mechanism of action of antipsychotics. However, the available data provide conflicting resul...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016688/

データ提供：米国国立医学図書館（NLM）

The Role of Cannabinoid Receptors in Neuroleptic-Induced Neurotensin Enhancement

Neuroleptic drugs, which are used to treat conditions like schizophrenia, can have complex effects on the brain, like a desert mirage playing tricks on the eyes. This study investigates the interaction between neuroleptics and brain neurotensin, a neuropeptide involved in various brain functions, focusing on the role of cannabinoid CB1 receptors.

Unraveling the Interplay of Neurochemicals

The authors examined the effects of two neuroleptics, fluphenazine and amisulpride, on brain neurotensin levels, considering the influence of cannabinoid CB1 receptors. They aimed to understand the mechanisms by which neuroleptics affect neurotensin neurotransmission, like exploring the intricate pathways of a desert oasis.

Exploring the Complexities of Brain Function

The study provides valuable insights into the complex interplay between neuroleptics, neurotensin, and cannabinoid CB1 receptors in the brain. The findings highlight the importance of understanding these interactions for developing more effective and targeted treatments for psychiatric disorders, like building a sustainable oasis in a harsh desert environment.

Dr.Camel's Conclusion

This study explores the intricate interplay between neuroleptics, neurotensin, and cannabinoid CB1 receptors in the brain. The findings suggest that targeting these pathways could lead to the development of more effective and targeted treatments for psychiatric disorders, offering a promising approach to addressing these complex conditions.

Date :
  1. Date Completed 2014-05-21
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24847420

DOI: Digital Object Identifier

PMC4016688

Related Literature

Article Analysis
・Effects of amisulpride injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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