Paper Details

  1. Home
  2. Paper Details

Acute toxic effects of single dose dacarbazine: hematological and histological changes in an animal model.

Author: KolarovićJ, Lalić-PopovićM, LaloševićD, MikovM, MilijaševićB, StefanovićD, TomićZ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the acute hematological and morphological changes caused by a single dose of dacarbazine (DTIC) in hamsters with fibrosarcoma. DTIC induced anemia, thrombocytopenia, and leukopenia, along with severe pneumonia, moderate hepatitis, and dose-related inhibition of tumor cell proliferation.
Paper Details　
Original Abstract of the Article :
Treatment of advanced soft tissue sarcoma usually includes dacarbazine (DTIC), an alkylating agent that methylates DNA and is active during all phases of the cell cycle. Common side effects of DTIC include nausea, vomiting, impaired liver and kidney function, myelosuppression, and pneumonia. There a...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3109/10520295.2014.918653

データ提供：米国国立医学図書館（NLM）

Dacarbazine: A Double-Edged Sword in Cancer Treatment

Cancer treatment is often a treacherous desert journey, with therapies carrying both benefits and risks. This study explores the acute toxic effects of dacarbazine (DTIC), a chemotherapy drug used to treat various cancers. Imagine a group of explorers, armed with the powerful weapon of DTIC, venturing into the desert of cancer, seeking to eradicate the disease but facing the potential consequences of this potent therapy.

Dacarbazine: A Powerful Weapon, But With Potential Risks

This study provides valuable insights into the potential side effects of DTIC. The study found that DTIC can cause significant hematological and histological changes in various organs, including the lungs, liver, and spleen. These findings underscore the importance of careful monitoring and management of DTIC therapy to minimize potential risks and maximize therapeutic benefits.

Navigating the Desert of Cancer Treatment

This study highlights the importance of understanding the potential toxic effects of chemotherapy drugs, like DTIC, and the need for personalized approaches to cancer treatment. It reinforces the importance of careful monitoring, risk-benefit assessment, and continuous improvement in cancer care to optimize patient outcomes.

Dr.Camel's Conclusion

This study provides valuable insights into the acute toxic effects of dacarbazine, a chemotherapy drug used to treat various cancers. The study's findings underscore the importance of careful monitoring and risk-benefit assessment when using DTIC, ensuring that the potential benefits of this potent therapy outweigh the potential risks. As researchers, we continue to explore the vast and complex landscape of cancer treatment, seeking to discover new therapies that are both effective and safe.

Date :
  1. Date Completed 2015-06-19
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

24867497

DOI: Digital Object Identifier

10.3109/10520295.2014.918653

Related Literature

Article Analysis
・Effects of dacarbazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.