Paper Details

  1. Home
  2. Paper Details

Methylnaltrexone: its pharmacological effects alone and effects on morphine in healthy volunteers.

Author: CoalsonDennis W, WroblewskiKristen, ZacnyJames P

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This article reviews the use of methylnaltrexone bromide (MTNX) for opioid-induced constipation. Studies suggest that MTNX may alter other opioid-induced effects besides constipation, highlighting the potential role of peripheral opioid actions.
Paper Details　
Original Abstract of the Article :
Methylnaltrexone bromide (MTNX) is a peripherally acting mu-opioid receptor antagonist, prescribed for the treatment of opioid-induced constipation in patients with advanced illness who are receiving palliative care. Studies have used this drug to determine if other opioid-induced effects besides co...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/24871705

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of Methylnaltrexone

This study explores the effects of methylnaltrexone bromide (MTNX), a medication that targets opioid receptors in the body, on healthy volunteers. MTNX is like a desert guide, helping to navigate the complex interactions of opioids within the body. Researchers are interested in understanding how MTNX affects various opioid-related effects, beyond its primary use in treating constipation. This research could be likened to mapping out the paths in a desert, identifying the different routes and destinations influenced by MTNX.

A Different Kind of Desert Oasis: Targeting Opioids

This study delves into the intricate world of opioid receptors, exploring how they respond to MTNX. The study indicates that MTNX might alter the effects of opioids beyond constipation, suggesting a wider range of potential applications for this medication. This is akin to finding a hidden oasis in the desert, revealing a new possibility for treatment strategies.

Navigating the Opioid Desert

Understanding the effects of MTNX on opioid receptors can be a valuable tool for managing various opioid-related effects, potentially leading to more effective treatment strategies and a more comfortable journey through the desert of opioid-related challenges.

Dr.Camel's Conclusion

This research sheds light on the intricate workings of opioid receptors and the potential benefits of MTNX. It’s like finding a guide through a complex desert, revealing new paths for managing opioid-related effects and improving the wellbeing of individuals.

Date :
  1. Date Completed 2015-10-16
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24871705

DOI: Digital Object Identifier

NIHMS599937

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.