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Pharmacogenetics of adverse events in schizophrenia treatment: comparison study of ziprasidone, olanzapine and perazine.

Author: BeszlejAleksander, BienkowskiPrzemyslaw, FrydeckaDorota, GrzywaczAnna, MierzejewskiPawel, SamochowiecAgnieszka, SamochowiecJerzy, Trześniowska-DrukałaBeata, TyburaPiotr

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study found no association between genetic polymorphisms and changes in body weight or extrapyramidal symptoms (EPS) related to antipsychotic treatment in paranoid schizophrenia patients.
Paper Details　
Original Abstract of the Article :
The primary aim of the present study was to assess the possible associations between dopaminergic, serotonergic, and glutamatergic system-related genes and adverse events after antipsychotic treatment in paranoid schizophrenia patients. The second aim of the study was to compare the intensity of the...See full text at original site
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引用元：
https://doi.org/10.1016/j.psychres.2014.05.039

データ提供：米国国立医学図書館（NLM）

Decoding the Genetic Landscape of Schizophrenia Treatment

The quest to understand and treat schizophrenia is a long and winding road, like a camel trek across the vast Sahara. This study dives into the genetic underpinnings of adverse events associated with antipsychotic treatment for paranoid schizophrenia. The researchers examined the influence of various genes related to dopamine, serotonin, and glutamate pathways on the development of side effects. They found that none of the investigated gene polymorphisms were associated with changes in body weight or extrapyramidal symptoms (EPS) after antipsychotic treatment. The study also compared the intensity of side effects between atypical and typical antipsychotic drugs.

Unraveling the Genetic Puzzle

The study found no association between the investigated gene polymorphisms and changes in body weight or EPS. This suggests that the genetic variations studied might not play a significant role in determining the likelihood of these specific side effects during antipsychotic treatment. This finding opens up new avenues for research, as other genetic factors might be involved.

Navigating the Side Effects

The study also revealed that olanzapine treatment was associated with the greatest weight increase, while ziprasidone was associated with the least. Perazine was associated with the highest intensity of EPS. These findings highlight the importance of considering individual factors and carefully monitoring side effects during antipsychotic treatment. It is important to discuss potential risks and benefits with your doctor to make informed decisions about your treatment plan.

Dr.Camel's Conclusion

This study sheds light on the intricate relationship between genes, antipsychotic treatment, and side effects in paranoid schizophrenia. The desert of schizophrenia research is vast and complex, but studies like this one bring us closer to understanding the individual responses to treatment and paving the way for more personalized and effective therapies.

Date :
  1. Date Completed 2014-12-16
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

24930580

DOI: Digital Object Identifier

10.1016/j.psychres.2014.05.039

Related Literature

Article Analysis
・Side Effects of ziprasidone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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