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Doxorubicin-induced behavioral disturbances in rats: protective effect of melatonin and captopril.

Author: AdamcovaM, ArendasovaK, AziriovaS, CelecP, HrenakJ, KamodyovaN, KrajcirovicovaK, PaulisL, RajkovicovaR, Repova BednarovaK, SimkoF, ZoradS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated whether doxorubicin administration could induce behavioral disturbances in rats and whether captopril or melatonin could modify these potential alterations.
Paper Details　
Original Abstract of the Article :
Doxorubicin is a recognized chemotherapeutic agent widely employed in human malignancies. The limiting factor of its use is a number of side effects. The aim of this work was to show, whether administration of doxorubicin could induce behavioral disturbances in rats, and whether angiotensin-converti...See full text at original site
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引用元：
https://doi.org/10.1016/j.pbb.2014.06.021

データ提供：米国国立医学図書館（NLM）

Doxorubicin: A Powerful Chemotherapeutic Agent with Side Effects

Doxorubicin is a widely used chemotherapy drug, but its use can be limited by various side effects. This study investigates the potential [behavioral disturbances] induced by doxorubicin in rats and explores the protective effects of [melatonin] and [captopril]. The researchers found that doxorubicin can induce behavioral changes in rats and that both melatonin and captopril may offer some protection against these disturbances. This research provides insights into the potential neurotoxic effects of doxorubicin and suggests that these effects may be mitigated by specific treatments. Further research is needed to confirm these findings and explore the clinical implications for human patients.

Melatonin and Captopril: Potential Protectors Against Doxorubicin's Side Effects

This research suggests that melatonin and captopril could potentially offer protection against the neurotoxic effects of doxorubicin. While further research is needed to confirm these findings in humans, the study provides a promising avenue for exploring new approaches to mitigating the side effects of chemotherapy.

Doxorubicin: A Double-Edged Sword in Cancer Treatment

Doxorubicin, a powerful weapon in the fight against cancer, can also have unintended consequences. This research highlights the need for careful monitoring of patients receiving doxorubicin and the potential role of agents like melatonin and captopril in mitigating these side effects.

Dr.Camel's Conclusion

The desert of cancer treatment is a challenging landscape, with powerful drugs like doxorubicin often coming with side effects. This research provides valuable insights into the potential neurotoxicity of doxorubicin and offers hope for developing new strategies to minimize its side effects and improve patient outcomes.

Date :
  1. Date Completed 2015-05-19
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

24983779

DOI: Digital Object Identifier

10.1016/j.pbb.2014.06.021

Related Literature

Article Analysis
・Side Effects of captopril
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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