Paper Details

  1. Home
  2. Paper Details

Silymarin alleviates bleomycin-induced pulmonary toxicity and lipid peroxidation in mice.

Author: Ali-OmraniMehdi, AmaniNahid, BagheriPezhman, Haji-NoormohammadiMehdi, Razavi-AzarkhiaviKamal, SepandMohammad-Reza, SolgiReza

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The study investigated the effect of silymarin on oxidative and inflammatory parameters in the lungs of mice exposed to bleomycin. The study found that silymarin attenuated bleomycin-induced pulmonary toxicity by keeping oxidant-antioxidant balance and regulating inflammatory mediator release.
Paper Details　
Original Abstract of the Article :
CONTEXT: The application of bleomycin is limited due to its side effects including lung toxicity. Silymarin is a flavonoid complex isolated from milk thistle [Silybum marianum L. (Asteraceae)] which has been identified as an antioxidant and anti-inflammatory compound. OBJECTIVE: This study evaluate...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3109/13880209.2014.889176

データ提供：米国国立医学図書館（NLM）

Silymarin: A Potential Remedy for Bleomycin-Induced Lung Toxicity

The use of medications, like navigating a vast desert, can sometimes lead to unexpected side effects. This study explores the potential of silymarin, a flavonoid complex derived from milk thistle, to alleviate bleomycin-induced pulmonary toxicity.

Silymarin's Protective Effects on Lung Health

The researchers found that silymarin effectively attenuated bleomycin-induced lung toxicity in mice, reducing lipid peroxidation and inflammation. This protective effect is attributed to silymarin's antioxidant and anti-inflammatory properties.

Silymarin's Role in Lung Health

Silymarin's ability to protect against bleomycin-induced lung toxicity suggests its potential for mitigating drug-related side effects and promoting lung health. It's like finding a restorative oasis in the desert, providing a refuge from the damaging effects of environmental stressors.

Dr.Camel's Conclusion

This study highlights the potential of silymarin as a protective agent against bleomycin-induced lung toxicity. Further research is needed to validate its clinical efficacy, but silymarin offers a promising avenue for mitigating drug-related side effects and improving lung health.

Date :
  1. Date Completed 2015-06-22
  2. Date Revised 2014-09-11
Further Info :

Pubmed ID

25026360

DOI: Digital Object Identifier

10.3109/13880209.2014.889176

Related Literature

Article Analysis
・Side Effects of milk thistle
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.