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Harmful effects of the azathioprine metabolite 6-mercaptopurine in vascular cells: induction of mineralization.

Author: HöhneMatthias, PrüferJasmin, PrüferNicole, SchuchardtMirjam, TölleMarkus, ZidekWalter, van der GietMarkus

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of 6-mercaptopurine (6-MP), an immunosuppressive drug, on vascular calcification. The study found that 6-MP could promote vascular calcification in laboratory tests. This finding suggests that 6-MP may have a harmful effect on blood vessels.
Paper Details　
Original Abstract of the Article :
Vascular mineralization contributes to the high cardiovascular morbidity and mortality in patients who suffer from chronic kidney disease and in individuals who have undergone solid organ transplantation. The immunosuppressive regimen used to treat these patients appears to have an impact on vascula...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100760/

データ提供：米国国立医学図書館（NLM）

Azathioprine: A Double-Edged Sword for Vascular Health?

The cardiovascular system is a complex network, and like a vast desert, it can be susceptible to various challenges. This study, published in the journal Atherosclerosis, examines the potential harmful effects of azathioprine, an immunosuppressive drug, on vascular health. This research delves into the potential of azathioprine to contribute to vascular calcification, a process that can lead to hardening of the arteries and increased risk of cardiovascular disease.

Azathioprine: A Potential Risk for Vascular Health

The study found that azathioprine can induce vascular mineralization, potentially contributing to the development of cardiovascular disease. This research highlights the potential risks associated with azathioprine and underscores the importance of careful monitoring and consideration of alternative treatments when possible.

Navigating the Risks of Immunosuppressive Therapy

This study underscores the importance of carefully weighing the benefits and risks of immunosuppressive therapies. While these drugs are essential for managing autoimmune diseases and preventing transplant rejection, it is critical to be aware of their potential side effects and to monitor patients closely for any signs of vascular complications.

Dr. Camel's Conclusion

This research adds to our understanding of the potential side effects of azathioprine and highlights the need for careful monitoring of patients receiving this immunosuppressive drug. It is a reminder that the desert of cardiovascular health requires careful attention and a thorough understanding of the potential risks and benefits of various medications.

Date :
  1. Date Completed 2015-03-09
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

25029363

DOI: Digital Object Identifier

PMC4100760

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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