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Involvement of microRNA181a in differentiation and cell cycle arrest induced by a plant-derived antioxidant carnosic acid and vitamin D analog doxercalciferol in human leukemia cells.

Author: DuggalJyoti, HarrisonJonathan S, StudzinskiGeorge P, WangXuening

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Doxercalciferol (1-D2) is a drug that is being investigated as a treatment for acute myeloid leukemia (AML). This study found that 1-D2 could induce differentiation of AML cells, which means that the cells become more like normal blood cells. The study also found that carnosic acid, a plant-derived antioxidant, could enhance the effects of 1-D2. This study suggests that 1-D2, with or without carnosic acid, could be a promising new treatment for AML.
Paper Details　
Original Abstract of the Article :
1,25-dihydroxyvitamin D3 (1,25D) has been shown to influence differentiation, cell proliferation and cell death in cultured leukemia cells. However, i...See full text at original site
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引用元：
https://doi.org/10.2174/2211536611201010026

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2014-12-11
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

25048087

DOI: Digital Object Identifier

10.2174/2211536611201010026

Related Literature

Article Analysis
・Effects of doxercalciferol
SNS
PICO Info
in preparation
Languages

English

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