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Effects of cytochrome P450 2C9 polymorphism on bosentan metabolism.

Author: CaiJianping, ChenMengchun, DaiDapeng, HuGuoxin, JinHui, PanPeipei, WangLi, WangXianqin, XiaMengmin, ZhanYunyun, ZhangYouting

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cytochrome P450 (P450) 2C9 is an important member of the P450 enzyme superfamily. This study assessed the catalytic activities of 38 human CYP2C9 alleles towards bosentan. The findings suggest that more attention should be directed to subjects carrying certain infrequent CYP2C9 alleles when administering bosentan in the clinic.
Paper Details　
Original Abstract of the Article :
Cytochrome P450 (P450) 2C9 is an important member of the P450 enzyme superfamily, with 58 CYP2C9 allelic variants previously reported. Genetic polymorphisms of CYP2C9 significantly influence the efficacy and safety of some drugs, which might cause adverse effects and therapeutic failure. The aim of ...See full text at original site
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引用元：
https://doi.org/10.1124/dmd.114.060244

データ提供：米国国立医学図書館（NLM）

Bosentan Metabolism and CYP2C9 Polymorphism: A Complex Interaction

Drug metabolism is a fascinating process, like a delicate dance between enzymes and medications in the body. Genetic variations can influence how drugs are metabolized, potentially affecting their efficacy and safety. This study focuses on the impact of CYP2C9 polymorphism, a genetic variation in a crucial enzyme, on the metabolism of bosentan, a drug used to treat pulmonary arterial hypertension.

The researchers investigated the catalytic activities of various CYP2C9 alleles, including some rare variants, towards bosentan. They discovered that some alleles significantly increased or decreased the metabolism of bosentan, potentially affecting drug concentrations in the body and influencing treatment outcomes.

Personalized Medicine: Tailoring Treatment Based on Genetic Makeup

This study highlights the importance of considering individual genetic variations when prescribing drugs. This approach, known as personalized medicine, can help optimize treatment strategies and minimize side effects. It's like customizing the caravan's supplies and equipment based on the specific needs of each camel and the challenges of the desert terrain.

Dr. Camel's Conclusion

This study is like a camel caravan navigating a complex desert landscape, highlighting the importance of understanding individual differences in drug metabolism. This knowledge can help healthcare providers tailor drug therapies for patients, improving treatment outcomes and ensuring the safety of their patients.

Date :
  1. Date Completed 2015-06-15
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

25142737

DOI: Digital Object Identifier

10.1124/dmd.114.060244

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・Effects of bosentan
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in preparation
Languages

English

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