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Dosing feasibility and tolerability of intranasal diazepam in adults with epilepsy.

Author: BreamGary, CarrazanaEnrique J, HaasKevin F, HenneyHerbert R, KraussGregory, RabinowiczAdrian L, Seif EddeineHussam, SperlingMichael R, SquillacoteDavid

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Diazepam nasal spray (diazepam-NS) was found to be feasible and effective in treating seizures in adults with epilepsy. Therapeutic concentrations were achieved when administered during convulsive tonic-clonic seizures or in the postictal periods following tonic-clonic or other seizure types.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To determine the feasibility of administering a diazepam nasal spray formulation (diazepam-NS) to adults with epilepsy during a generalized tonic-clonic seizure or in the postictal period following a tonic-clonic or other seizure type, to assess pharmacokinetics and to assess tolerability...See full text at original site
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引用元：
https://doi.org/10.1111/epi.12755

データ提供：米国国立医学図書館（NLM）

Intranasal Diazepam: A New Frontier in Epilepsy Treatment

This research explores the feasibility and tolerability of intranasal diazepam, a new formulation of the anticonvulsant medication diazepam, for the treatment of seizures in adults with epilepsy. The authors conducted a study to investigate the pharmacokinetics and pharmacodynamics of intranasal diazepam, evaluating its effectiveness and safety in managing seizures.

Intranasal Diazepam: A Promising New Delivery Method

The study findings suggest that intranasal diazepam is a feasible and well-tolerated treatment option for seizures in adults with epilepsy. The authors demonstrate that intranasal diazepam achieves therapeutic concentrations in the blood and can effectively control seizures. The study also highlights the convenience and ease of administration of intranasal diazepam, making it a potentially valuable tool for managing seizures in the home setting.

Empowering Epilepsy Management

This research offers hope for individuals with epilepsy, providing a new and potentially more convenient approach to seizure management. Intranasal diazepam offers a promising alternative to traditional oral or intravenous administration, potentially improving seizure control and quality of life for individuals with epilepsy. This research encourages further exploration of intranasal diazepam and its potential for improving epilepsy care.

Dr. Camel's Conclusion

This research presents a compelling case for intranasal diazepam as a feasible and well-tolerated treatment option for seizures in adults with epilepsy. The study highlights the potential for intranasal diazepam to improve seizure control and quality of life for individuals with epilepsy, offering a promising new approach to epilepsy management.

Date :
  1. Date Completed 2015-01-26
  2. Date Revised 2014-10-21
Further Info :

Pubmed ID

25154625

DOI: Digital Object Identifier

10.1111/epi.12755

Related Literature

Article Analysis
・Effects of diazepam nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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