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Clinical presentation of Paget's disease: evaluation of a contemporary cohort and systematic review.

Author: RalstonStuart H, TanAdrian

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Paget's disease of bone (PDB) is becoming less common, but it's unclear if this has affected how the disease presents. This study examined the symptoms of PDB in a recent group of UK patients and reviewed previous studies. Bone pain was the most common symptom (73.8% of patients), followed by bone deformities (18.1%), deafness (7.9%), and fractures (5.7%). About 22% of people had no symptoms. Treatment with medications that slow bone breakdown relieved pain in 61.7% of patients. People with shorter disease duration were more likely to respond to treatment. A review of past studies showed that fractures were less common in recent years, while pain was more common. While the way PDB presents has changed, many people still experience complications like fractures and deformities. More research is needed to determine if early detection and treatment could prevent these problems.
Paper Details　
Original Abstract of the Article :
Paget's disease of bone (PDB) has become less common over recent decades but it is unclear if this has impacted on clinical presentation. Here we evaluated the presenting features of PDB in a contemporary cohort of UK patients and conducted a systematic review of studies in which the presenting feat...See full text at original site
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引用元：
https://doi.org/10.1007/s00223-014-9904-1

データ提供：米国国立医学図書館（NLM）

Paget's Disease of Bone: A Contemporary Perspective

Paget's disease of bone (PDB) is a chronic bone disorder that has been studied for decades. This research delves into the evolving clinical presentation of PDB, examining a contemporary cohort of patients in the UK. The study employs a comprehensive approach, combining a case series with a systematic review to provide a multifaceted analysis of PDB. The authors meticulously examine the presenting features of PDB, identifying the most common symptoms, such as bone pain, deformity, deafness, and pathological fracture. They also explore the impact of disease duration on treatment response. The study reveals that while the incidence of PDB has declined, the disease still presents with significant complications. This research emphasizes the need for continued research to improve early detection and treatment strategies for PDB, ultimately leading to better outcomes for patients.

The Importance of Early Detection and Treatment for PDB

This study highlights the importance of early detection and treatment for PDB. The researchers found that patients with a shorter disease duration were more likely to respond to antiresorptive treatment. This finding underscores the critical role of early intervention in managing PDB and preventing complications. It also emphasizes the need for greater awareness of PDB among healthcare providers and the public to facilitate early diagnosis and prompt treatment.

Managing the Effects of PDB on Your Life

PDB can have a significant impact on a person's life, affecting mobility, bone strength, and overall well-being. If you experience any persistent bone pain, deformities, or other symptoms related to PDB, consulting a healthcare professional is crucial. Early diagnosis and appropriate treatment can help manage the symptoms and prevent complications. Remember, just as a camel adapts to the arid desert environment, individuals with PDB can learn to manage their condition and live fulfilling lives.

Dr.Camel's Conclusion

Just like a camel navigating through the vast and ever-changing desert landscape, our understanding of PDB is constantly evolving. This research helps us better understand the modern face of PDB, highlighting the importance of early detection and proactive treatment to minimize its impact. The journey to manage PDB may require a combination of medical expertise, personal resilience, and perhaps even a bit of camel-like adaptation to the challenges it presents.

Date :
  1. Date Completed 2015-06-16
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

25160936

DOI: Digital Object Identifier

10.1007/s00223-014-9904-1

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PICO Info
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Languages

English

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