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[Effects and related mechanism of retinoid X receptor agonist bexarotene on atherosclerosis progression in diabetic apoE(-/-) mice].

Author: ChaiDajun, LinJinxiu, NingRuobing, XuChangsheng, ZhuJiang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 46 apolipoprotein E knockout (apoE(-/-)) mice found that bexarotene treatment could attenuate arteriosclerosis progression in streptozotocin (STZ) induced diabetic apoE(-/-) mice. The mechanism might be related to suppressing oxidative stress, decreasing blood glucose levels, and improving lipid metabolism.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To explore the effect of retinoid X receptor (RXR) agonist bexarotene on atherosclerosis and the potential mechanism in streptozotocin (STZ) induced diabetic apolipoprotein E knockout (apoE(-/-)) mice. METHODS: Eight C57BL/6 mice served as control, 46 apoE(-/-) mice were randomized into ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/25164224

データ提供：米国国立医学図書館（NLM）

Bexarotene: A Potential Ally in the Fight Against Atherosclerosis

Atherosclerosis, a condition characterized by plaque buildup in the arteries, is a major risk factor for heart disease. This study investigates the effects of bexarotene, a retinoid X receptor (RXR) agonist, on atherosclerosis progression in diabetic apolipoprotein E knockout (apoE(-/-)) mice. The researchers found that bexarotene treatment significantly reduced plaque area in the aorta, suggesting a potential protective effect against atherosclerosis.

Bexarotene: A Potential Weapon Against Plaque Buildup

The study provides promising evidence that bexarotene could be a valuable tool in the fight against atherosclerosis. Its ability to reduce plaque formation in diabetic mice suggests that it may have a similar effect in humans.

A Guiding Star in the Desert of Heart Disease

Atherosclerosis is like a creeping desert storm, slowly encroaching upon the arteries. Bexarotene, like a guiding star, could help to prevent the formation of plaque, potentially reducing the risk of heart disease. However, further research is needed to confirm its efficacy in humans.

Dr.Camel's Conclusion

This study offers a hopeful glimpse into the potential of bexarotene in preventing atherosclerosis. More research is needed, but it's a promising development for the future of cardiovascular health.

Date :
  1. Date Completed 2014-12-29
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25164224

DOI: Digital Object Identifier

25164224

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Article Analysis
・Effects of bexarotene
SNS
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in preparation
Languages

Chinese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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