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Rabeprazole exhibits antiproliferative effects on human gastric cancer cell lines.

Author: GuMengli, JiFeng, MaHan, YaoHangping, ZhangYan, ZhouXinxin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Rabeprazole, a proton pump inhibitor, was found to reduce the viability of gastric cancer cells in vitro by inhibiting the ERK1/2 signaling pathway. The study found that rabeprazole significantly decreased the viability of MKN-28 cells and induced apoptosis in AGS cells. Rabeprazole completely inhibited the phosphorylation of ERK 1/2 in MKN-28 cells, suggesting a potential role as a novel antineoplastic agent.
Paper Details　
Original Abstract of the Article :
Intracellular proton extrusion in gastric cancer cells has been reported to promote cancer cell survival under acidic conditions via hydrogen/potassium adenosine triphosphatase (H<sup>+</sup>/K<sup>+</sup>-ATPase). Rabeprazole is a frequently used second-generation proton pump inhibitor (PPI) that i...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156221/

データ提供：米国国立医学図書館（NLM）

Rabeprazole: A Potential New Weapon Against Gastric Cancer?

Gastric cancer is a serious health concern with limited treatment options. This study investigated the potential antiproliferative effects of rabeprazole, a proton pump inhibitor commonly used to treat acid reflux, on human gastric cancer cell lines. The researchers aimed to explore the potential of rabeprazole as a novel antineoplastic agent.

Rabeprazole: A Promising Antiproliferative Agent for Gastric Cancer

The study revealed that rabeprazole effectively inhibited the viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway. The findings suggest that rabeprazole may have a potential role in treating gastric cancer. This study provides promising evidence for the potential of rabeprazole as a new treatment option for gastric cancer, opening new avenues for research and development.

Rabeprazole: A Potential New Hope for Gastric Cancer Patients?

This research offers a glimmer of hope for patients with gastric cancer. Rabeprazole, a commonly prescribed drug for acid reflux, demonstrates the potential to inhibit the growth of gastric cancer cells. While more research is needed to confirm its effectiveness and safety in treating gastric cancer, this study suggests that rabeprazole may have a role in future cancer therapies.

Dr. Camel's Conclusion

This study reveals the potential of rabeprazole, a proton pump inhibitor commonly used to treat acid reflux, as a novel antineoplastic agent for gastric cancer. The findings suggest that rabeprazole may effectively inhibit the growth of gastric cancer cells. This research provides a promising starting point for further investigations into the use of rabeprazole as a new treatment option for gastric cancer.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

25202402

DOI: Digital Object Identifier

PMC4156221

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in preparation
Languages

English

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