Paper Details 
Original Abstract of the Article :
Impairment of dopamine function, which is known to have major effects on behaviors and cognition, is one of the main problems associated with cerebral ischemia. Tadalafil, a long-acting phosphodiesterase type-5 inhibitor, is known to ameliorate neurologic impairment induced by brain injury, but not ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146079/

データ提供:米国国立医学図書館(NLM)

Tadalafil: A Potential Neuroprotector in the Wake of a Stroke

The brain is a complex and delicate organ, and stroke can have devastating effects. This study investigates the potential neuroprotective effects of tadalafil, a drug commonly used to treat erectile dysfunction, in the aftermath of a stroke. The researchers used gerbils as their model, inducing stroke-like conditions and then administering tadalafil. They then examined the impact on specific brain regions and chemicals involved in brain function.

Tadalafil: A Potential Ally in the Fight Against Stroke Damage

The study findings are quite promising, showing that tadalafil may have neuroprotective effects in the aftermath of a stroke. They found that tadalafil boosted levels of a crucial brain chemical, cyclic guanosine monophosphate (cGMP), and positively influenced the function of dopamine neurons, which play a key role in movement and cognition. These results suggest that tadalafil could potentially help to minimize the damage caused by stroke.

Protecting Your Brain: A Tale of Two Brains

This study reminds us that the brain, like a desert oasis, is a precious resource that needs to be protected. While tadalafil may show promise as a neuroprotector after stroke, it's important to remember that preventing stroke in the first place is crucial. Maintaining a healthy lifestyle, managing risk factors like high blood pressure, and seeking medical attention promptly if you experience any stroke symptoms can help to protect your brain from the ravages of this devastating condition.

Dr.Camel's Conclusion

Just like a camel navigating a treacherous sandstorm, the brain needs protection from the storm of a stroke. This study suggests that tadalafil may offer a potential lifeline in the aftermath of stroke, but prevention is always the best course of action. Remember, a healthy brain is a precious treasure!

Date :
  1. Date Completed 2014-09-10
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

25206715

DOI: Digital Object Identifier

PMC4146079

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Languages

English

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