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In vitro percutaneous absorption and metabolism of ozenoxacin in excised human skin.

Author: GropperSavion, OrtizJordi, SantosBenjamin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the percutaneous absorption and skin metabolism of ozenoxacin using excised human skin samples. Across all absorption studies, less than 0.015% of the applied ozenoxacin dose permeated through the skin over 24 or 48 hours. Ozenoxacin was metabolically stable in the presence of human skin discs.
Paper Details　
Original Abstract of the Article :
In vitro studies using excised human skin samples were conducted to evaluate the percutaneous absorption and skin metabolism of ozenoxacin. The formulations studied were 1% ointment, 1% cream and 2% cream. Permeation assays met the conditions for infinite dose experiments. In all but one case, ozeno...See full text at original site
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引用元：
https://doi.org/10.2217/fmb.14.81

データ提供：米国国立医学図書館（NLM）

Ozenoxacin's Percutaneous Absorption and Metabolism

Ozenoxacin is a topical antibiotic used to treat skin infections. This study investigates the percutaneous absorption and metabolism of ozenoxacin in excised human skin. The authors used in vitro studies to evaluate the absorption of ozenoxacin from different formulations (ointment and cream) and assess its metabolic stability in the presence of human skin. The study found that ozenoxacin has very low percutaneous absorption and is metabolically stable in human skin.

Ozenoxacin: A Safe and Effective Topical Antibiotic

This study provides valuable information about the pharmacokinetics of ozenoxacin, confirming its low absorption through the skin and its metabolic stability in human skin. These findings suggest that ozenoxacin is a safe and effective topical antibiotic, minimizing the risk of systemic side effects and ensuring its efficacy in treating skin infections.

Think About It Like a Desert Sand

Imagine a desert sand dune, impassable by foot but easily traversed by a camel. Similarly, ozenoxacin, a topical antibiotic, stays on the surface of the skin, treating infections without traveling deep into the body. This study demonstrates that ozenoxacin is effective in treating skin infections without causing systemic side effects, like a camel navigating the desert safely and effectively.

Dr.Camel's Conclusion

This study provides valuable insights into the pharmacokinetics of ozenoxacin, a topical antibiotic. The low percutaneous absorption and metabolic stability in human skin suggest that ozenoxacin is a safe and effective topical treatment option for skin infections.

Date :
  1. Date Completed 2015-05-18
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

25209522

DOI: Digital Object Identifier

10.2217/fmb.14.81

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Article Analysis
・Effects of ozenoxacin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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