Randomized dose range study of a recombinant hepatitis B vaccine produced in mammalian cells and containing the S and PreS2 sequences.

Author: AdamowiczP, BenhamouJ P, BréchotC, CouroucéA M, DegosF, GoudeauA, LaplancheA, MarieF N, SaliouP, TronF

Paper Details 
Original Abstract of the Article :
The safety and immunogenicity of different doses (2, 5, 10, and 20 micrograms of a recombinant hepatitis B virus (rHBV) vaccine containing the S and PreS2 sequences and produced in mammalian cells were compared to those of a plasma-derived hepatitis B virus vaccine (Hevac B Pasteur) in 482 volunteer...See full text at original site
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引用元:
https://doi.org/10.1093/infdis/160.2.199

データ提供:米国国立医学図書館(NLM)

Recombinant Hepatitis B Vaccine: A New Oasis in the Desert of Viral Prevention

Hepatitis B is a serious viral infection that can lead to liver damage and other health problems. This study investigates the safety and immunogenicity of a new recombinant hepatitis B vaccine produced in mammalian cells. The researchers compared different doses of this vaccine to a plasma-derived vaccine, aiming to determine the optimal dose for effective immunization.

A Promising New Vaccine: A Beacon of Hope in the Desert of Hepatitis B

The study found that the new recombinant hepatitis B vaccine was safe and immunogenic, with similar seroconversion rates to the plasma-derived vaccine. The researchers concluded that the 10- and 20-microgram doses of the recombinant vaccine were as effective as the plasma-derived vaccine and elicited higher antibody levels compared to lower doses. The recombinant vaccine also showed an advantage in terms of early and high production of antibodies to PreS2, a protein associated with viral entry.

Protecting Against Hepatitis B: A Journey Towards Healthier Futures

This research offers a potential new weapon in the fight against hepatitis B. It's like discovering a new oasis in the vast desert of viral infections. The study's findings suggest that the new recombinant vaccine is safe and effective, potentially leading to better protection against this serious disease. It's a reminder that innovation and research continue to offer hope for healthier futures.

Dr.Camel's Conclusion

This research highlights the potential of a new recombinant hepatitis B vaccine to offer effective protection against this serious infection. It's like discovering a new oasis in the vast desert of viral infections. The study's findings suggest that this vaccine could be a valuable tool for preventing hepatitis B, offering hope for a healthier future.

Date :
  1. Date Completed 1989-09-08
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2527274

DOI: Digital Object Identifier

10.1093/infdis/160.2.199

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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