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Cardiomyocytes are Protected from Antiretroviral Nucleoside Analog-Induced Mitochondrial Toxicity by Overexpression of PGC-1α.

Author: Crespo-MejiasYasmin, GibbonsAlexander, LiuDaniel, LiuYongmin, NguyenPhuongGiang, PoirierMiriam C, ShideEric, ShimEunwoo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Overview

This study investigated the protective effects of PGC-1α overexpression against nucleoside reverse transcriptase inhibitor (NRTI)-induced mitochondrial toxicity in cardiomyocytes. PGC-1α overexpression was found to protect cardiomyocytes from NRTI-induced growth inhibition, apoptosis, and oxidative stress.
Paper Details　
Original Abstract of the Article :
The nucleoside reverse transcriptase inhibitors (NRTIs), used for treatment of the human immunodeficiency virus-1, compromise mitochondria in cardiomyocytes and other host cells, limiting the clinical use of these drugs. To explore underlying mechanisms, we overexpressed PGC-1α, a master regulator o...See full text at original site
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引用元：
https://doi.org/10.1007/s12012-014-9288-5

データ提供：米国国立医学図書館（NLM）

PGC-1α: A Shield Against Antiretroviral Toxicity

Antiretroviral nucleoside analogs (NRTIs) are crucial for treating HIV-1 infection, but they can have unintended consequences, particularly for heart cells. Think of these drugs as a double-edged sword, effectively fighting the virus but potentially harming healthy cells. This study investigates the protective role of PGC-1α, a key regulator of mitochondrial function, against NRTI-induced toxicity.

The researchers overexpressed PGC-1α in heart cells and exposed them to a combination of NRTIs, AZT and ddI. They discovered that PGC-1α overexpression significantly protected the cells from the toxic effects of the drugs. It's like building a protective sandcastle around the heart cells, shielding them from the harsh effects of the NRTIs.

PGC-1α: A Promising Target for Protecting Heart Health

The study provides compelling evidence for the protective role of PGC-1α in mitigating the toxic effects of NRTIs on heart cells. This discovery could potentially lead to the development of new strategies for protecting heart health during HIV-1 treatment. It's like finding a new oasis in the desert of antiretroviral toxicity, offering a safe haven for heart cells.

Keeping Your Heart Strong in the Desert of HIV-1 Treatment

HIV-1 treatment can be a double-edged sword, providing effective viral suppression but potentially impacting heart health. This study offers a ray of hope, highlighting the potential of PGC-1α to protect heart cells from the harmful effects of antiretroviral drugs. It's like finding a hidden wellspring of protection in the desert of HIV-1 treatment, ensuring that your heart remains strong and resilient.

Dr.Camel's Conclusion

This study demonstrates the potential of PGC-1α to protect cardiomyocytes from NRTI-induced toxicity. This discovery holds significant promise for improving the long-term health outcomes of individuals receiving antiretroviral therapy, minimizing the potential cardiovascular risks associated with these essential treatments.

Date :
  1. Date Completed 2016-02-29
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

25377427

DOI: Digital Object Identifier

10.1007/s12012-014-9288-5

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Languages

English

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