Crizotinib effects on creatinine and non-creatinine-based measures of glomerular filtration rate.

Author: BrosnanEvelyn M, CamidgeD Ross, ChoncholMichel, DeSilvaChamath, KooPhillip J

Paper Details 
Original Abstract of the Article :
Rapid reductions in creatinine-based estimates of the glomerular filtration rate (GFR) have recently been reported secondary to crizotinib use. Whether these reflect drug-induced changes in the true GFR or the validity of creatinine as a measure of kidney function in the presence of crizotinib is un...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/25436798

データ提供:米国国立医学図書館(NLM)

Exploring the Effectiveness of Crizotinib on Kidney Function

Navigating the intricate world of medication and its impact on our bodies is like navigating a vast, complex desert. This research delves into the effects of crizotinib, a drug used to treat cancer, on kidney function. The researchers observed a decrease in creatinine levels, a measure of kidney health, in patients taking crizotinib. However, they questioned whether this change reflected a true decline in kidney function or simply a peculiarity of creatinine measurement in the presence of crizotinib, like the shifting sands of a desert obscuring the true landscape. Their findings are like a trail of breadcrumbs, guiding further research into the complex interplay between crizotinib and kidney function.

Unraveling the Mystery of Crizotinib and Kidney Function

This research offers a valuable glimpse into the complex relationship between crizotinib and kidney function. The researchers found that crizotinib can affect creatinine levels, but they cautioned that this may not necessarily reflect a decline in kidney function. It's like uncovering a hidden oasis in the desert of medical knowledge, revealing a new perspective on how medications can interact with our bodies. This study highlights the need for further research to better understand the impact of crizotinib on kidney function, ensuring that patients receive safe and effective treatment.

Navigating Crizotinib Treatment with Informed Caution

The findings of this research are like a map, guiding doctors and patients through the potential challenges of crizotinib treatment. They emphasize the importance of monitoring kidney function closely in patients taking crizotinib, ensuring that any changes are promptly addressed. This study highlights the need for a comprehensive approach to cancer treatment, considering not only the effectiveness of the medication but also its potential impact on other organs. It's a reminder to be vigilant, just as a traveler must be wary of hidden dangers in the desert.

Dr.Camel's Conclusion

This study is a reminder of the need to delve deeper into the intricate interactions between medications and our bodies. It's a valuable guide, helping us navigate the complex landscape of cancer treatment with more knowledge and understanding.

Date :
  1. Date Completed 2015-12-09
  2. Date Revised 2019-02-21
Further Info :

Pubmed ID

25436798

DOI: Digital Object Identifier

S1556-0864(15)30730-9

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Languages

English

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