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Inhibitory effects of Pycnogenol® on hepatitis C virus replication.

Author: BenjellounSoumaya, EzzikouriSayeh, InoueKazuaki, KinoYoichiro, KoharaMichinori, MatsumoriAkira, NishimuraTomohiro, Tsukiyama-KoharaKyoko

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pycnogenol, a natural extract, showed antiviral effects against hepatitis C virus (HCV) in cell and animal models. It also showed synergy with interferon-alpha and ribavirin, suggesting a potential role in improving existing HCV treatments.
Paper Details　
Original Abstract of the Article :
Chronic hepatitis C virus (HCV) infection increases the risk of liver cirrhosis and hepatocellular carcinoma. In the last decade, the current standard HCV treatment, pegylated interferon and ribavirin, have limited efficacy and significant side effects. Novel direct acting antivirals show promise, b...See full text at original site
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引用元：
https://doi.org/10.1016/j.antiviral.2014.10.017

データ提供：米国国立医学図書館（NLM）

Pycnogenol®: A Potential Adjunct to Hepatitis C Treatment

Hepatitis C virus (HCV) infection can lead to serious liver disease, including cirrhosis and liver cancer. This study investigates the antiviral effects of Pycnogenol®, a natural extract from French maritime pine bark, on HCV replication.

The researchers evaluated the effects of Pycnogenol® on both wild-type and protease inhibitor-resistant HCV replicon cells. They also investigated the combination effects of Pycnogenol® with interferon-alpha, ribavirin, and telaprevir. Additionally, they studied the effects of Pycnogenol® in HCV-infected chimeric mice.

The study found that Pycnogenol® exhibited antiviral effects against HCV replication without causing cytotoxicity. Furthermore, Pycnogenol® showed synergistic effects when combined with interferon-alpha or ribavirin. The researchers also observed that Pycnogenol® inhibited HCV replication in telaprevir-resistant cells. They concluded that Pycnogenol® may be a valuable adjunct to current HCV antiviral therapies.

New Hope for Hepatitis C Treatment

This study, like a camel discovering a hidden water source in the desert, offers hope for a new approach to managing HCV infection. Pycnogenol® shows promise as a natural antiviral agent that can potentially enhance the effectiveness of current treatments and address the challenge of drug resistance.

Understanding Hepatitis C Treatment Options

Hepatitis C treatment is a complex process. This study provides valuable information about Pycnogenol®'s potential as an adjunct therapy. However, it's crucial to discuss treatment options with a healthcare professional who specializes in liver diseases to determine the best course of action for your specific situation.

Dr. Camel's Conclusion

This study, like a camel finding a refreshing oasis in the desert, sheds light on the potential of Pycnogenol® in combating HCV infection. It's a promising new approach, but more research is needed to fully understand its role in HCV treatment. Remember, always consult with a healthcare professional to determine the best path for your health.

Date :
  1. Date Completed 2015-08-10
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25446333

DOI: Digital Object Identifier

10.1016/j.antiviral.2014.10.017

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Languages

English

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