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Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells.

Author: AuriolaSeppo, Coimbra de SousaSofia, EbertRegina, GraserStephanie, HofbauerLorenz C, JakobFranz, Meissner-WeiglJutta, MentrupBirgit, MäättäJorma, RachnerTilman D, ZeckSabine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study hypothesized that enhancing intracellular pyrophosphate accumulation via inhibition of probenecid-sensitive channels and transporters would sensitize tumor cells for bisphosphonates anti-tumor efficacy.
Paper Details　
Original Abstract of the Article :
Anti-resorptive bisphosphonates (BP) are used for the treatment of osteoporosis and bone metastases. Clinical studies indicated a benefit in survival and tumor relapse in subpopulations of breast cancer patients receiving zoledronic acid, thus stimulating the debate about its anti-tumor activity. Am...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295226/

データ提供：米国国立医学図書館（NLM）

A New Approach to Combating Breast Cancer: Sensitizer for Bisphosphonate

Imagine the battle against breast cancer as a vast desert, where scientists are constantly searching for new ways to fight the disease. This research explores a promising strategy: using probenecid as a sensitizer to enhance the effectiveness of bisphosphonates in treating breast cancer.

A Novel Approach: Enhancing the Power of Bisphosphonates

This study investigates the potential of probenecid to sensitize breast cancer cells to the effects of bisphosphonates, drugs commonly used to treat osteoporosis and bone metastases. By increasing intracellular pyrophosphate accumulation, probenecid may enhance the ability of bisphosphonates to inhibit cancer cell growth and promote apoptosis. This approach could lead to more effective and targeted therapies for breast cancer.

A New Oasis in the Desert of Cancer Treatment

This research offers hope for new and more effective treatment strategies for breast cancer. By exploring the use of probenecid as a sensitizer, scientists may be able to unleash the full potential of bisphosphonates in the fight against cancer. This innovative approach could provide a vital new oasis in the desert of cancer treatment, offering hope for patients and a new front in the battle against this devastating disease.

Dr.Camel's Conclusion

This research is an exciting step in the fight against breast cancer. By exploring the use of probenecid to enhance the effectiveness of bisphosphonates, scientists are opening new doors to more effective and targeted treatments. This innovative approach holds promise for improving the lives of patients and creating a brighter future for cancer treatment.

Date :
  1. Date Completed 2015-07-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25496233

DOI: Digital Object Identifier

PMC4295226

Related Literature

Article Analysis
・Effects of probenecid
SNS
PICO Info
in preparation
Languages

English

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