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Contemporary aspects of the biology and therapeutic regulation of the microsomal triglyceride transfer protein.

Author: BurnettJohn R, HooperAmanda J, WattsGerald F

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This review focuses on the microsomal triglyceride transfer protein (MTP), its role in lipoprotein assembly, and its implications in abetalipoproteinemia, a rare genetic disorder characterized by MTP deficiency. The review explores MTP inhibitors, including lomitapide, and their potential benefits and limitations in treating dyslipidemia and cardiovascular disease.
Paper Details　
Original Abstract of the Article :
The microsomal triglyceride transfer protein (MTP), the product of the MTTP gene, is essential for the assembly and secretion of apolipoprotein B-containing lipoproteins, but when defective causes abetalipoproteinemia. Abetalipoproteinemia is a rare autosomal recessive disorder characterized by the ...See full text at original site
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引用元：
https://doi.org/10.1161/CIRCRESAHA.116.304637

データ提供：米国国立医学図書館（NLM）

Microsomal Triglyceride Transfer Protein: Unveiling the Secrets of Lipid Metabolism

This review explores the biology and therapeutic regulation of microsomal triglyceride transfer protein (MTP), a key player in lipid metabolism. Imagine the body's lipid pathways as a complex network of desert roads, with MTP acting as a crucial traffic controller, ensuring the smooth flow of lipids. The researchers delve into the intricacies of MTP function, examining its role in both health and disease.

They explain that MTP is essential for the assembly and secretion of lipoproteins, which are responsible for transporting fats throughout the body. When MTP function is disrupted, it can lead to abetalipoproteinemia, a rare disorder characterized by the inability to produce certain lipoproteins. The review also discusses the development of MTP inhibitors as potential treatments for dyslipidemia, exploring the challenges and opportunities associated with this approach.

The Significance of MTP in Lipid Metabolism

The review underscores the vital role of MTP in lipid metabolism. Understanding the intricacies of MTP function can contribute to the development of effective therapies for lipid-related disorders.

MTP: A Potential Target for Lipid Disorders

The review highlights the potential of MTP inhibitors as a therapeutic strategy for dyslipidemia. These inhibitors may offer a valuable tool for managing lipid levels and reducing the risk of cardiovascular disease. Just as a desert explorer needs to carefully manage their supplies and resources, healthcare professionals must carefully navigate the complexities of lipid metabolism to ensure optimal health.

Dr. Camel's Conclusion

This review provides a comprehensive overview of the biology and therapeutic regulation of microsomal triglyceride transfer protein. It sheds light on the crucial role of MTP in lipid metabolism and its potential as a target for treating lipid-related disorders. As we continue to explore the vast desert of medical knowledge, understanding the intricacies of MTP function can lead to new discoveries and innovative treatments.

Date :
  1. Date Completed 2015-03-20
  2. Date Revised 2015-01-01
Further Info :

Pubmed ID

25552696

DOI: Digital Object Identifier

10.1161/CIRCRESAHA.116.304637

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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