Paper Details

  1. Home
  2. Paper Details

The effects of the atypical antipsychotic asenapine in a strain-specific battery of tests for mania-like behaviors.

Author: EinatHaim, EneHila M, KaraNirit Z

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the effects of asenapine, an antipsychotic drug, in a mouse model of manic-like behaviors. Asenapine, at doses of 0.1 and 0.3 mg/kg, demonstrated antimanic-like effects, reducing activity, increasing immobility in a forced-swim test, and reducing amphetamine-induced hyperactivity. These findings support the potential use of asenapine for treating bipolar disorder.
Paper Details　
Original Abstract of the Article :
Asenapine is indicated for the treatment of schizophrenia and manic episodes in bipolar disorder (BPD). There is a paucity of information on the effects of asenapine in animal models of BPD, but such work is essential to discover its scope of effects and its mechanisms of therapeutic action. This st...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1097/FBP.0000000000000128

データ提供：米国国立医学図書館（NLM）

Asenapine: A Potential Oasis in the Desert of Bipolar Disorder

Bipolar disorder (BPD), a complex mental illness characterized by alternating periods of mania and depression, can significantly impact an individual's life. This study explores the potential of asenapine, an atypical antipsychotic, in treating manic-like behaviors in a mouse model of BPD. The researchers administered asenapine to Black Swiss mice and assessed their behavior in a battery of tests designed to model manic-like symptoms.

The results showed that asenapine exhibited antimanic-like effects in some of the behavioral tests, reducing activity, increasing immobility, and attenuating amphetamine-induced hyperactivity. These findings suggest that asenapine may have potential therapeutic value in the treatment of BPD, particularly for managing manic episodes.

Finding Calm in the Storm of BPD

This study offers a glimpse into the potential of asenapine in treating BPD. The research findings, while promising, require further investigation to fully understand the drug's efficacy and safety in humans. However, these results provide a foundation for future research and clinical trials, which could lead to improved treatments for individuals with BPD.

Navigating the Desert of Bipolar Disorder

This study offers a glimmer of hope in the desert of BPD treatment. The research findings suggest that asenapine may be a valuable tool in managing manic episodes, but further investigation is crucial to confirm its effectiveness and safety in humans. The journey towards effective treatments for BPD is ongoing, and researchers continue to explore new and innovative approaches to manage this complex and challenging condition.

Dr. Camel's Conclusion

This study highlights the potential of asenapine as a treatment for BPD, offering a glimmer of hope in the desert of this complex and challenging condition. Further research is needed to confirm these findings and to understand the drug's efficacy and safety in humans.

Date :
  1. Date Completed 2016-01-13
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

25590966

DOI: Digital Object Identifier

10.1097/FBP.0000000000000128

Related Literature

Article Analysis
・Effects of asenapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.