Synergistic effects of crizotinib and radiotherapy in experimental EML4-ALK fusion positive lung cancer.

Author: AbdollahiAmir, DaiYing, DebusJürgen, LipsonKenneth E, MoustafaMahmoud, SchwagerChristian, WeiQuanxiang, WeichertWilko, ZhouCheng

Paper Details 
Original Abstract of the Article :
BACKGROUND AND PURPOSE: Non-small cell lung cancer (NSCLC) patients with chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) are sensitive to the tyrosine kinase inhibitor crizotinib. We aimed to investigate the effects of combined radiotherapy and crizotinib in ALK-positive vs. ...See full text at original site
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引用元:
https://doi.org/10.1016/j.radonc.2014.12.009

データ提供:米国国立医学図書館(NLM)

Crizotinib and Radiotherapy: A Powerful Alliance Against ALK-Positive Lung Cancer

Lung cancer, a formidable adversary, often requires a multi-pronged approach to treatment. This study focuses on crizotinib, a targeted therapy for ALK-positive non-small cell lung cancer (NSCLC), and investigates its potential synergy with radiotherapy. The researchers are exploring whether crizotinib, like a skilled archer, can be combined with radiotherapy, like a well-aimed arrow, to effectively target cancer cells.

Crizotinib and Radiotherapy: A Synergistic Approach

This study, like a camel caravan traversing a desert landscape, reveals the potential for synergistic effects when combining crizotinib and radiotherapy in treating ALK-positive NSCLC. The research demonstrates that this combination, like a well-coordinated team of travelers navigating a challenging terrain, can be more effective than either treatment alone. The study also highlights the potential for using crizotinib to enhance the efficacy of both photon and carbon ion radiotherapy.

A Powerful Alliance Against Cancer

This study, like a beacon of hope in the desert of cancer research, underscores the importance of exploring innovative treatment strategies for ALK-positive NSCLC. The findings suggest that combining crizotinib with radiotherapy can be a potent weapon against this challenging disease, offering a brighter future for patients.

Dr.Camel's Conclusion

This study, like a caravan of researchers venturing into a challenging landscape, highlights the potential of combining crizotinib with radiotherapy to effectively treat ALK-positive non-small cell lung cancer. The findings suggest that this synergistic approach, like a well-coordinated team of travelers navigating a challenging terrain, can offer a more effective and promising treatment strategy for patients.
Date :
  1. Date Completed 2015-08-10
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25592111

DOI: Digital Object Identifier

10.1016/j.radonc.2014.12.009

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