Paper Details

  1. Home
  2. Paper Details

Effects of l-penbutolol (Hoe 893d) on the transmembrane potentials of canine purkinje fibers and ventricular muscle fibers.

Author: HirataY, IwamuraN, KodamaI, ShimizuT, ToyamaJ, YamadaK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The beta-adrenergic blocking action and intrinsic membrane effects of penbutolol were investigated. Penbutolol reduced the rate of depolarization and shortened action potential duration in heart cells. The drug was also effective in antagonizing the effects of isoproterenol on heart cells, suggesting a high degree of beta-adrenergic blocking specificity.
Paper Details　
Original Abstract of the Article :
Intrinsic membrane effects (non-specific effects) and beta-adrenergic blocking action (specific effects) of l-penbutolol were studied using intracellular microelectrode techniques. l-Penbutolol in concentrations above 0.1 mg/L reduced the maximum rate of depolarization at phase O of both Purkinje fi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/25633

データ提供：米国国立医学図書館（NLM）

Penbutolol: A Targeted Beta-Blocker

This study, published in 1981, explores the effects of l-penbutolol, a beta-blocker used to manage heart conditions, on the electrical activity of heart cells. The researchers, like electricians working on a complex circuit, investigated the specific and non-specific effects of l-penbutolol on the heart's rhythm and function.

Penbutolol: A Highly Specific Beta-Blocker

The study found that l-penbutolol, like a skilled surgeon performing a delicate operation, selectively blocked the effects of adrenaline on the heart, without significantly affecting other electrical activities. This finding suggests that l-penbutolol might be a highly specific and safe beta-blocker.

Navigating the Desert of Heart Health

It is essential to remember that every camel's heart has its own rhythm. The right beta-blocker for you will depend on your individual needs and health history. Always consult with a healthcare professional to determine the most suitable treatment for your heart condition.

Dr. Camel's Conclusion

This study, like a caravan navigating a challenging terrain, provides valuable insights into the effects of l-penbutolol on the heart's electrical activity. The research highlights the potential of l-penbutolol to be a highly specific and safe beta-blocker, offering a promising treatment option for those seeking to manage their heart health.
Date :
  1. Date Completed 1978-06-28
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

25633

DOI: Digital Object Identifier

25633

Related Literature

Article Analysis
・Effects of penbutolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.