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Denosumab and osteonecrosis of the jaw. A systematic analysis of events reported in clinical trials.

Author: Aguilar-SalvatierraAntonio, Boquete-CastroAna, Calvo-GuiradoJosé Luis, Delgado-RuizRafael Arcesio, Gómez-MorenoGerardo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This meta-analysis investigates the relationship between denosumab treatment and the incidence of osteonecrosis of the jaw (ONJ). The review also explores the dosage, timing of first event appearance, and treatment approaches for ONJ related to denosumab.
Paper Details　
Original Abstract of the Article :
The aims of this meta-analysis were (i) to perform a systematic review of the relation between treatment with denosumab and the incidence of osteonecrosis of the jaw (ONJ) and (ii) to obtain information on dosage, first event apparition, and treatment approaches for patients with ONJ related to deno...See full text at original site
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引用元：
https://doi.org/10.1111/clr.12556

データ提供：米国国立医学図書館（NLM）

Denosumab and Osteonecrosis of the Jaw: A Systematic Analysis of the Shifting Sands of Risk

The desert of bone health is a complex terrain, where researchers constantly seek to understand the potential risks associated with various medications. This meta-analysis examines the relationship between denosumab, a medication used to treat osteoporosis, and the incidence of osteonecrosis of the jaw (ONJ). The researchers, like skilled camel caravan guides, carefully analyze the data from clinical trials, seeking to identify potential risk factors and inform clinical practice. This study delves into the potential complications associated with denosumab, providing valuable insights for clinicians and patients.

Navigating the Desert of Bone Health: Understanding the Risks of Denosumab

The study's findings, like a carefully mapped desert, reveal the potential risk of ONJ associated with denosumab treatment. This research, like a cautionary tale in the vast landscape of bone health, highlights the importance of weighing the benefits and risks of denosumab treatment and considering individual patient factors.

Navigating the Desert of Bone Health: A Journey Towards Informed Decisions

This meta-analysis underscores the importance of careful consideration when prescribing denosumab, ensuring that the benefits outweigh the potential risks. The findings highlight the need for ongoing monitoring and informed decision-making in the management of osteoporosis, ensuring the best possible outcomes for patients.

Dr. Camel's Conclusion

This meta-analysis highlights the potential risk of ONJ associated with denosumab treatment, emphasizing the importance of careful consideration and informed decision-making. The findings underscore the need for ongoing monitoring and patient education to ensure the safe and effective use of denosumab in the management of osteoporosis. This research serves as a valuable guidepost in the ongoing quest for safe and effective treatments for bone health.

Date :
  1. Date Completed 2017-07-17
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

25639776

DOI: Digital Object Identifier

10.1111/clr.12556

Related Literature

Article Analysis
・Effective treatment of osteonecrosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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