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The effect of metronidazole on the cell cycle and DNA in metronidazole-susceptible and -resistant Giardia cell lines.

Author: NohynkovaEva, UzlikovaMagdalena

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to describe the effects of MTZ treatment on DNA and cell cycle progression in MTZ-sensitive and in vitro-derived MTZ-resistant cell lines.
Paper Details　
Original Abstract of the Article :
Metronidazole (MTZ) is used as the drug of choice to treat Giardia infections. It is believed that the prodrug is transformed intracellularly into toxic intermediates that interact with cellular components, leading to cell death. The present study aimed to describe the effects of MTZ treatment on DN...See full text at original site
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引用元：
https://doi.org/10.1016/j.molbiopara.2015.01.005

データ提供：米国国立医学図書館（NLM）

Metronidazole: Unraveling the Mechanism of Action

This study explores the complex world of [pharmacology] and [parasite resistance]. The research investigates the effects of [metronidazole] on [Giardia cell lines], comparing [metronidazole-susceptible] and [metronidazole-resistant] strains. The study sheds light on the mechanism by which [metronidazole] exerts its effects, highlighting the role of [DNA damage] and [cell cycle disruption]. Interestingly, the study suggests that [DNA damage] may contribute to the development of [metronidazole resistance] in [Giardia], providing valuable insights for understanding the emergence of drug resistance in parasites.

The Double-Edged Sword of Metronidazole: A Look at Resistance

This research explores the potential for [metronidazole resistance] in [Giardia], a parasite that can cause intestinal infections. The findings suggest that [metronidazole] can induce [DNA damage], which may contribute to the development of resistance. This information is crucial for understanding the evolution of drug resistance in parasites and for developing strategies to combat it.

Combating Parasite Resistance: A Continuing Challenge

This study highlights the ever-present challenge of [parasite resistance] to [antiparasitic drugs]. The findings suggest that [metronidazole] can induce [DNA damage] in [Giardia], which may contribute to the development of resistance. This emphasizes the importance of ongoing research into the mechanisms of drug resistance and the development of new strategies to combat it.

Dr.Camel's Conclusion

Just like a camel navigating a desert landscape, we must be vigilant in our efforts to combat [parasite resistance]. This research sheds light on the potential for [metronidazole resistance] in [Giardia], reminding us that the fight against these microscopic foes is a constant one. It's like battling the shifting sands of the desert, requiring constant adaptation and innovation to overcome the challenges.
Date :
  1. Date Completed 2015-10-02
  2. Date Revised 2015-03-23
Further Info :

Pubmed ID

25681616

DOI: Digital Object Identifier

10.1016/j.molbiopara.2015.01.005

Related Literature

Article Analysis
・Effective treatment of giardia infections
SNS
PICO Info
in preparation
Languages

English

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