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Investigating Antithyroid Effects of Propylthiouracil on the Ischemia and Reperfusion Injury in Rat' Kidney and Determining the Role of Nitric Oxide in Mediating this Effect.

Author: DormaneshBanafshe, EmamiHamed, Moazen JamshidiSeyed Mir Mansoor, TofangchihaShahnaz

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Renal ischemia/reperfusion injury is a major problem in kidney transplantation. Propylthiouracil (PTU) is a drug that has been shown to protect against renal ischemia/reperfusion injury in animal studies. PTU may work by increasing the production of nitric oxide, which helps to protect the kidneys from damage.
Paper Details　
Original Abstract of the Article :
Renal ischemia/reperfusion injury (IRI) is a major problem in renal transplantation, which occurs during the process of organ retrieval and storage, and is closely associated with acute rejection episodes and late allograft failure. Recent studies have revealed a new phenomenon called "chemical prec...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329750/

データ提供：米国国立医学図書館（NLM）

Propylthiouracil: A Potential Protector Against Renal Ischemia-Reperfusion Injury

This study investigates the antithyroid effects of propylthiouracil (PTU) on ischemia and reperfusion injury (IRI) in rat kidneys. The research delves into the potential protective role of PTU against IRI, a major complication in renal transplantation, by exploring the role of nitric oxide (NO) in mediating this effect. This study contributes to our understanding of the potential therapeutic applications of PTU in renal transplantation, particularly in mitigating IRI and enhancing graft survival.

Propylthiouracil: A Potential Shield Against Renal Damage

This study reveals the potential protective effects of propylthiouracil (PTU) against renal ischemia-reperfusion injury (IRI). The findings suggest that PTU, known for its antithyroid properties, may possess additional therapeutic benefits in the context of renal transplantation. This research opens up promising avenues for exploring PTU as a potential therapeutic agent for mitigating IRI and improving graft survival.

Propylthiouracil: A Beacon of Hope in the Desert of Renal Transplantation

Renal transplantation offers a beacon of hope for patients with end-stage renal disease. However, the desert of IRI can pose a significant challenge to graft survival. This study unveils the potential protective effects of PTU, highlighting its promise as a potential therapeutic agent for mitigating IRI and enhancing graft outcomes.

Dr.Camel's Conclusion

This study investigates the potential antithyroid effects of propylthiouracil (PTU) on ischemia and reperfusion injury (IRI) in rat kidneys. The findings suggest that PTU may possess protective properties against IRI, a major complication in renal transplantation. This research opens up promising avenues for exploring PTU as a potential therapeutic agent for mitigating IRI and improving graft survival.
Date :
  1. Date Completed 2015-03-12
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

25763197

DOI: Digital Object Identifier

PMC4329750

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・Effects of propylthiouracil
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in preparation
Languages

English

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