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The Serotonin 2C Receptor Agonist Lorcaserin Attenuates Intracranial Self-Stimulation and Blocks the Reward-Enhancing Effects of Nicotine.
Author: FletcherPaul J, HigginsGuy A, ZeebFiona D
Original Abstract of the Article :
Lorcaserin, a serotonin (5-hydroxytryptamine, 5-HT) 2C receptor agonist, was recently approved for the treatment of obesity. We previously suggested that 5-HT2C receptor agonists affect reward processes and reduce the rewarding effects of drugs of abuse. Here, we determined whether lorcaserin (1) de...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1021/acschemneuro.5b00017
データ提供:米国国立医学図書館(NLM)
Lorcaserin: A New Weapon in the Battle Against Obesity and Addiction
Obesity is a complex and multifaceted health problem, and researchers are constantly seeking new ways to treat this growing epidemic. This study examines the effects of lorcaserin, a medication approved for weight loss, on reward processes in the brain. The researchers used a technique called intracranial self-stimulation (ICSS), which allows animals to self-administer electrical stimulation to rewarding brain regions, to assess the effects of lorcaserin on reward-seeking behavior.
They found that lorcaserin reduced responding for brain stimulation reward and blocked the reward-enhancing effects of nicotine, suggesting that the drug may be effective in treating both obesity and nicotine addiction by reducing the rewarding value of food and drugs. This research sheds light on the potential of lorcaserin as a multi-faceted therapeutic agent for a range of behavioral and health issues.
Lorcaserin: A Multi-faceted Approach to Combating Obesity and Addiction
The study’s findings are groundbreaking, as they suggest that lorcaserin could be a promising therapeutic agent for both obesity and nicotine addiction. By targeting the brain’s reward pathways, the drug could help individuals break free from unhealthy cravings and behaviors, ultimately leading to a healthier and more fulfilling life.
Lorcaserin: A Potential Tool for Healthy Choices
This research highlights the importance of understanding the brain’s reward mechanisms in addressing complex health issues like obesity and addiction. While more research is needed, lorcaserin holds promise as a potential tool to help individuals make healthier choices and overcome unhealthy cravings. Just as a camel navigates the vast desert, lorcaserin can guide individuals toward a healthier path, breaking free from the shackles of unhealthy habits and cravings.
Dr.Camel's Conclusion
The desert of addiction and obesity can be a daunting place, but lorcaserin offers a beacon of hope. By reducing the allure of unhealthy rewards, this medication could empower individuals to make healthier choices and break free from these challenging conditions. This study is a testament to the power of research and its potential to improve human health and well-being.
Date :
- Date Completed 2016-04-19
- Date Revised 2015-07-15
Further Info :
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