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Dose dependent protective effects of vardenafil on ischemia-reperfusion injury with biochemical and histopathologic evaluation in rat ovary.

Author: CaydereMuzaffer, CicekNedim, HucumenogluSema, KaratasYeksin H, OzyerSebnem, SeckinKerem D, TogrulCihan, UzunlarOzlem, YurtcuEngin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Low and high dose vardenafil is effective in attenuating ischemia-reperfusion induced ovary injury in rats.
Paper Details　
Original Abstract of the Article :
PURPOSE: The purpose of the study is to evaluate the effect of vardenafil on the histopathology and biochemical parameters in reducing damage in experimental ovarian ischemia and ischemia/reperfusion injury in a rat model and to compare the effect of two different doses of vardenafil. METHODS: Fort...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpedsurg.2014.12.013

データ提供：米国国立医学図書館（NLM）

Vardenafil's Protective Effects on Ischemia-Reperfusion Injury in the Rat Ovary

The ovary, a delicate organ, is essential for female reproductive health. This study investigates the potential protective effects of vardenafil, a drug used to treat erectile dysfunction, on ischemia-reperfusion injury in the rat ovary. Researchers explore the ability of vardenafil to reduce damage to the ovary caused by temporary blood flow restriction and subsequent restoration. The study examines the effects of vardenafil on biochemical markers and histopathological changes in the ovary.

Vardenafil's Potential for Protecting the Ovary

This study provides evidence that vardenafil may offer protective effects against ischemia-reperfusion injury in the ovary. The authors found that vardenafil reduced the extent of damage to the ovary, suggesting its potential for protecting this vital organ. Just as a desert plant adapts to periods of drought, vardenafil appears to help the ovary withstand the challenges of blood flow disruption.

Exploring New Therapeutic Applications for Existing Drugs

This study highlights the potential for repurposing existing drugs for new therapeutic applications. The researchers' exploration of vardenafil's effects on the ovary demonstrates the importance of exploring the multifaceted properties of medications. This research is a reminder that we can often find new solutions by looking at familiar things in a fresh light.

Dr.Camel's Conclusion

This study provides promising evidence that vardenafil may have protective effects against ischemia-reperfusion injury in the ovary. It underscores the importance of exploring new therapeutic applications for existing drugs and the potential benefits of this approach for improving patient health.
Date :
  1. Date Completed 2016-02-18
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

25783344

DOI: Digital Object Identifier

10.1016/j.jpedsurg.2014.12.013

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Article Analysis
・Effects of vardenafil
SNS
PICO Info
in preparation
Languages

English

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