Chimeric fusion proteins used for therapy: indications, mechanisms, and safety.

Author: BaldoBrian A

Paper Details 
Original Abstract of the Article :
Chimeric fusion proteins, produced by genetic engineering, are currently made up of effector peptides, for example, a ligand-binding portion of a cytokine or growth factor, extracellular domains of lymphocyte antigens, or a toxin linked to a suitable fusion partner. This review covers eight fusion p...See full text at original site
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引用元:
https://doi.org/10.1007/s40264-015-0285-9

データ提供:米国国立医学図書館(NLM)

Chimeric Fusion Proteins: A New Frontier in Therapy

The field of biotherapeutics is constantly evolving, seeking innovative approaches to treating diseases. Chimeric fusion proteins, created through genetic engineering, combine different protein fragments to create novel therapeutic molecules. This research explores the use of these fusion proteins in therapy, examining their mechanisms, indications, and safety.

The study reviews eight fusion proteins that have received regulatory approval for human therapy, highlighting their diverse applications in treating conditions like arthritis, psoriasis, and cancer. The study discusses the key features of effective fusion proteins, including targeted delivery, cytotoxicity, and stability.

The study also addresses the potential adverse effects of fusion protein therapy, emphasizing the importance of assessing immunogenicity risk. These proteins can trigger immune responses, potentially leading to allergic reactions and other adverse events. The study highlights the need for careful monitoring and management of these risks.

A New Era of Biotherapeutics

This research, like a camel carrying precious cargo across a vast desert, highlights the promise of chimeric fusion proteins as a new era of biotherapeutics. Their targeted delivery and potential for treating a range of conditions offer hope for patients facing complex diseases.

Navigating the Desert of Side Effects

The study reminds us that, like a camel navigating a treacherous desert, the journey to effective treatment involves careful consideration of potential risks and side effects. Understanding the immunogenicity of fusion proteins is crucial for ensuring patient safety and optimizing treatment outcomes.

Dr.Camel's Conclusion

This research, like a camel carrying a precious cargo of knowledge through a vast desert, explores the potential of chimeric fusion proteins in therapy. These innovative molecules offer hope for treating various diseases, but careful monitoring and understanding of their immunogenicity are essential for ensuring patient safety and maximizing their therapeutic benefits.

Date :
  1. Date Completed 2016-01-20
  2. Date Revised 2022-08-01
Further Info :

Pubmed ID

25832756

DOI: Digital Object Identifier

10.1007/s40264-015-0285-9

SNS
PICO Info
in preparation
Languages

English

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