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The ocular surface side effects of an anti-psychotic drug, clozapine.

Author: Aksu CeylanNihan, CeylanErdinç, KartalBaki, OzerMuhammet Derda, Yildiz EkinciDilbade, YilmazYusuf Cem, ÇiniciEmine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Long-term clozapine usage was found to induce dry eye syndrome and lead to morphological alterations in corneal parameters, such as reduced corneal thickness and tear film stability. These changes may impact glaucoma patients and candidates for corneal refractive surgery.
Paper Details　
Original Abstract of the Article :
PURPOSE: The purpose of this study is to investigate the effects of long-term clozapine usage on tear film stability and corneal topographic parameters. MATERIAL AND METHODS: The study was conducted between March 2014 and November 2014. Thirty patients who were diagnosed of schizophrenia and have b...See full text at original site
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引用元：
https://doi.org/10.3109/15569527.2015.1018387

データ提供：米国国立医学図書館（NLM）

The Ocular Surface Side Effects of Clozapine

This research delves into the potential ocular surface side effects of clozapine, an antipsychotic drug commonly used to treat schizophrenia. The researchers conducted a comparative study examining the tear film stability and corneal topographic parameters of patients on long-term clozapine therapy versus healthy controls.

Uncovering the Ocular Impact of Clozapine

The study found statistically significant differences in corneal parameters and tear film stability between the two groups. Patients on clozapine exhibited reduced tear film stability, thinner corneas, and altered corneal topography, suggesting the potential for clozapine to induce dry eye syndrome. This research highlights the importance of considering potential ocular side effects in patients on long-term clozapine therapy, particularly when evaluating those with conditions like glaucoma or selecting candidates for corneal refractive surgery.

Navigating Clozapine Treatment

This study reminds us that the effects of medications extend beyond their intended therapeutic targets. It's essential to be aware of the potential for side effects, especially when treating chronic conditions. Careful monitoring of ocular health in patients on clozapine therapy can help mitigate potential complications and ensure optimal treatment outcomes.

Dr.Camel's Conclusion

This research underscores the importance of considering the wider impact of medications on the human body, even those used for seemingly unrelated conditions. It encourages us to expand our understanding of drug interactions and side effects, striving for a more holistic approach to patient care. By continuing to investigate these connections, we can work towards safer and more effective treatments for all.
Date :
  1. Date Completed 2016-12-15
  2. Date Revised 2016-12-30
Further Info :

Pubmed ID

25853177

DOI: Digital Object Identifier

10.3109/15569527.2015.1018387

Related Literature

Article Analysis
・Side Effects of clozapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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