Effects of the orexin receptor antagonist suvorexant on respiration during sleep in healthy subjects.

Author: DonikyanMardik, LinesChristopher, LiuRong, LouridasBonnie, MarsilioSabrina, McCreaJacqueline, SunHong, TroyerMatthew D, UemuraNaoto, WagnerJohn, ZammitGary

Paper Details 
Original Abstract of the Article :
Suvorexant is an orexin receptor antagonist for treating insomnia. The maximum approved dose in the United States and Japan is 20 mg. We evaluated suvorexant effects on respiration during sleep in a randomized, double-blind, 3-period crossover study of healthy adult men (n = 8) and women (n = 4) ≤ 5...See full text at original site
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引用元:
https://doi.org/10.1002/jcph.523

データ提供:米国国立医学図書館(NLM)

Suvorexant: A Sleep Aid with No Respiratory Side Effects?

Insomnia can feel like wandering through a never-ending desert of sleepless nights. Suvorexant, a medication designed to bring sleep to weary travelers, has been investigated for its potential respiratory effects. This study, like a careful camel caravan traversing the dunes, meticulously measured the effects of suvorexant on sleep breathing in healthy individuals. Researchers used a crossover study design, allowing each participant to experience all three conditions: placebo, 40 mg suvorexant, and 150 mg suvorexant. This approach, much like comparing different desert oases, provided a robust comparison of the drug's effects. The results, like a clear desert sky, revealed no significant effect of suvorexant on oxygen saturation or apnea-hypopnea index, the markers of sleep breathing quality. This finding suggests that suvorexant, at doses greater than those approved for insomnia treatment, does not compromise breathing during sleep.

Suvorexant's Safety: A Breath of Fresh Air

The absence of respiratory effects, even at high doses, provides a sense of relief for those seeking a peaceful night's rest. This study, like a steady camel caravan, offers reassurance for those seeking a safe and effective solution to insomnia.

Sleeping Soundly: A Guide for the Sleep-Deprived

Insomnia is a common ailment that can have far-reaching consequences on both mental and physical health. While this study provides promising insights about the safety of suvorexant, it is crucial to consult with a qualified medical professional for personalized advice and treatment plans.

Dr.Camel's Conclusion

This study, like a refreshing oasis in the desert of insomnia, offers a glimmer of hope for those seeking relief. It provides valuable information about the safety of suvorexant, suggesting that it may be a viable option for individuals struggling with sleep difficulties. As always, proper medical consultation is essential for navigating the unique challenges of insomnia.

Date :
  1. Date Completed 2016-06-22
  2. Date Revised 2015-09-03
Further Info :

Pubmed ID

25903940

DOI: Digital Object Identifier

10.1002/jcph.523

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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