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Micro-CT Analysis of Radiation-Induced Osteopenia and Bone Hypovascularization in Rat.

Author: BleryPauline, EspitalierFlorent, GuicheuxJérôme, MalardOlivier, MichelGuillaume, PiletPaul, WeissPierre

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Radiation therapy for carcinomas of the upper aerodigestive tract can cause mandibular osteoradionecrosis (ORN). This study found that irradiation significantly decreased intraosseous vascularization, cortical bone thickness, and total bone volume in a rat model of ORN.
Paper Details　
Original Abstract of the Article :
Treatment of carcinomas of the upper aerodigestive tract often requires external radiation therapy. However, radiation affects all the components of bone, with different degrees of sensitivity, and may produce severe side effects such as mandibular osteoradionecrosis (ORN). Intraosseous vascularizat...See full text at original site
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引用元：
https://doi.org/10.1007/s00223-015-0010-9

データ提供：米国国立医学図書館（NLM）

Radiation Therapy: A Double-Edged Sword for Bone Health

Radiation therapy is a powerful tool in the fight against cancer, but it can also have unintended consequences. This research explores the impact of radiation therapy on bone health, particularly in the context of mandibular osteoradionecrosis (ORN).

Radiation Therapy: Unveiling the Impact on Bone Microstructure

The study utilizes micro-CT analysis to investigate the effects of radiation on the bone microvasculature and structure. The results reveal that radiation therapy can lead to significant bone hypovascularization and osteopenia, creating a desert-like environment within the bone. This weakens the bone structure, increasing the risk of fractures and other complications.

Minimizing Bone Damage

This research highlights the importance of carefully considering the potential risks and benefits of radiation therapy, particularly in patients at risk for ORN. The study underscores the need for innovative approaches to minimize bone damage during radiation therapy.

Dr.Camel's Conclusion

Radiation therapy is like a desert oasis, offering a life-saving solution for cancer patients, but it can also create a harsh environment for bone health. This research provides valuable insights into the impact of radiation therapy on bone microstructure, paving the way for improved treatment strategies and better patient outcomes.

Date :
  1. Date Completed 2016-05-09
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

25953705

DOI: Digital Object Identifier

10.1007/s00223-015-0010-9

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English

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