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Time-dependent pharmacodynamic effects of phenobarbital in humans.

Author: BarzaghiN, GalimbertiC A, GattiG, ManniR, PeruccaE, TartaraA, ZuccaC

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Phenobarbital induces CNS-depressing effects, but tolerance develops rapidly. Multiple Sleep Latency Tests are more sensitive than other tests in documenting the sedative effects.
Paper Details　
Original Abstract of the Article :
The relationship between the serum concentration of phenobarbital and its pharmacodynamic effects was assessed in a double-blind controlled study in eight normal volunteers who were given single oral doses of phenobarbital (200 mg) and placebo according to a randomized cross-over design. Compared wi...See full text at original site
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引用元：
https://doi.org/10.1097/00007691-198911000-00009

データ提供：米国国立医学図書館（NLM）

Phenobarbital: A Journey Through the Sands of Pharmacodynamic Tolerance

This research investigates the pharmacodynamic effects of phenobarbital, a commonly used anticonvulsant, in humans. The study employs a double-blind, controlled design to evaluate the relationship between serum phenobarbital levels and its CNS-depressing effects. The authors uncover a rapid development of pharmacodynamic tolerance, even after a single dose of the drug. This finding highlights the dynamic nature of drug effects and underscores the importance of considering tolerance development in therapeutic strategies.

Phenobarbital: Unveiling the Sands of Tolerance

This study provides valuable insights into the pharmacodynamic effects of phenobarbital, particularly highlighting the rapid development of tolerance. This finding challenges traditional assumptions about drug effects and emphasizes the importance of individualized treatment approaches and careful monitoring of therapeutic outcomes.

Navigating the Sands of Phenobarbital Therapy

This research highlights the importance of understanding the dynamic nature of drug effects, particularly tolerance development. The study's findings underscore the need for individualized treatment approaches and careful monitoring of therapeutic outcomes to ensure optimal patient care. Like a camel navigating a desert, healthcare professionals must remain vigilant in their assessment of drug effects and adapt their strategies to ensure patient safety and well-being.

Dr. Camel's Conclusion

As a seasoned researcher who has traversed the vast deserts of pharmacology, I find this study's exploration of phenobarbital's pharmacodynamic effects particularly illuminating. The study's findings underscore the importance of understanding drug tolerance and its implications for treatment strategies. Just as a camel navigates a desert by adapting to its changing environment, healthcare professionals must remain vigilant in their assessment of drug effects and adapt their treatment approaches to ensure optimal patient care.

Date :
  1. Date Completed 1990-01-25
  2. Date Revised 2019-09-03
Further Info :

Pubmed ID

2595746

DOI: Digital Object Identifier

10.1097/00007691-198911000-00009

SNS
PICO Info
in preparation
Languages

English

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