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Phase I dose escalation trial of nitroglycerin in addition to 5-fluorouracil and radiation therapy for neoadjuvant treatment of operable rectal cancer.
Author: DowellJonathan E, HittsonWilliam J, HuertaSergio, IllumHenrik, MeyerJeffrey, TorrisiJohn R, WangDavid H
Original Abstract of the Article :
BACKGROUND: Nitric oxide donors decreased cell survival in vitro and tumor load in vivo in models of rectal cancer subjected to ionizing radiation. Nitroglycerin (NTG) transdermal patches, added to chemotherapy, have been shown to improve outcomes in lung cancer patients. METHODS: This open-label, ...See full text at original site
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引用元：
https://doi.org/10.1016/j.surg.2015.04.007
データ提供：米国国立医学図書館（NLM）
Nitroglycerin: A New Ally in the Fight Against Rectal Cancer?
Rectal cancer is a serious disease, and finding effective treatments is a top priority for medical researchers. This study explores the potential of nitroglycerin (NTG), a medication known for its vasodilating properties, as an adjunct to standard chemotherapy and radiation therapy for operable rectal cancer. The researchers conducted a phase I dose escalation trial to assess the safety, tolerability, and feasibility of adding NTG to the treatment regimen.
Nitroglycerin: A Promising Adjunct Therapy for Rectal Cancer
The findings suggest that NTG patches are well-tolerated and feasible to use in combination with chemotherapy and radiation therapy for rectal cancer. The study observed mild to moderate side effects, most of which were manageable. While the rate of pathological complete response (pCR), a measure of tumor eradication, was 17%, further research is needed to confirm the efficacy of NTG in improving outcomes for rectal cancer patients.
A New Frontier in Rectal Cancer Treatment: The Potential of Nitroglycerin
This research is like a caravan traversing a desert landscape, seeking new paths for improving rectal cancer treatment. Nitroglycerin, a familiar medication for heart conditions, emerges as a potential ally in the fight against this disease. While further research is needed to fully understand its role, this study offers a glimmer of hope for enhancing existing treatment strategies and improving outcomes for rectal cancer patients.
Dr.Camel's Conclusion
Rectal cancer is a formidable opponent, but this study unveils a potential new weapon: Nitroglycerin. Like a desert oasis, NTG offers a refreshing perspective on treatment options, showing promise as an adjunct therapy. However, further research is crucial to determine its true potential and ensure a safe journey for patients facing this challenging disease.
Date :
- Date Completed 2015-09-14
- Date Revised 2015-07-04
Further Info :
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