Is rivastigmine safe as pretreatment against nerve agents poisoning? A pharmacological, physiological and cognitive assessment in healthy young adult volunteers.

Author: AtsmonJacob, BlancaMerav, BrandeisRachel, EisenkraftArik, GrauerEttie, KrivoyAmir, LavonOphir, RamatyErez, RavehLily

Paper Details 
Original Abstract of the Article :
Rivastigmine, a reversible cholinesterase inhibitor, approved as a remedy in Alzheimer's disease, was suggested as pretreatment against nerve agents poisoning. We evaluated the pharmacokinetic, pharmacodynamic, physiologic, cognitive and emotional effects of repeated rivastigmine in young healthy ma...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.neuro.2015.05.003

データ提供:米国国立医学図書館(NLM)

Rivastigmine: A Promising Treatment for Nerve Agent Poisoning?

This study delves into the potential of rivastigmine, a medication used to treat Alzheimer's disease, as a preventative measure against nerve agent poisoning. The research utilizes a double-blind, placebo-controlled crossover trial to analyze the pharmacokinetic, pharmacodynamic, physiological, cognitive, and emotional effects of repeated rivastigmine administration in healthy young adults.

Complex Pharmacological Profile Limits Rivastigmine's Potential

The research reveals that rivastigmine, while showing some potential for preventing nerve agent poisoning, presents a complex pharmacological profile and high inter-personal variability. The study identifies significant variations in how individuals respond to rivastigmine, making it difficult to predict its effects and manage its use in an emergency situation.

Navigating the Complexities of Nerve Agent Poisoning: A Camel's Perspective

Imagine a desert traveler facing a sandstorm. Like a sandstorm that requires careful navigation and preparation, nerve agent poisoning demands a precise and predictable response. This research highlights the complexities of using rivastigmine for nerve agent poisoning. While it may offer a possible solution, further research is needed to address the variability in individual responses and ensure its safety and effectiveness.

Dr.Camel's Conclusion

While rivastigmine shows promise in treating Alzheimer's disease, its use as a pretreatment for nerve agent poisoning is complex and requires further research. The individual variability in response to rivastigmine makes it a challenging drug to manage in emergency situations. Further research is needed to understand how rivastigmine interacts with the body and to develop safer and more effective treatments for nerve agent poisoning.

Date :
  1. Date Completed 2016-04-25
  2. Date Revised 2015-08-03
Further Info :

Pubmed ID

26001567

DOI: Digital Object Identifier

10.1016/j.neuro.2015.05.003

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.