Effect of renal impairment on the pharmacokinetics of levomilnacipran following a single oral dose of levomilnacipran extended-release capsule in humans.

Author: Brand-SchieberElimor, ChenLaishun, GhahramaniParviz, GreenbergWilliam M, PericlouAntonia, WangsaJulie

Paper Details 
Original Abstract of the Article :
PURPOSE: Levomilnacipran extended-release (ER) is indicated for treatment of major depressive disorder in adults. We evaluated the pharmacokinetic and safety profile of levomilnacipran ER in individuals with impaired renal function. METHODS: A total of 32 individuals participated in four groups (ei...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485797/

データ提供:米国国立医学図書館(NLM)

Levomilnacipran: A Journey Through the Desert of Renal Impairment

Levomilnacipran, a medication used to treat major depressive disorder, is a powerful tool in the fight against this challenging mental health condition. This study explores the impact of renal impairment on the pharmacokinetics of levomilnacipran. The researchers evaluated the pharmacokinetic profile of levomilnacipran in individuals with different levels of renal impairment, providing valuable insights for safe and effective medication management.

A Navigational Guide: Renal Impairment and Levomilnacipran Pharmacokinetics

The study, like a camel caravan navigating a desert terrain, reveals the impact of renal impairment on the pharmacokinetics of levomilnacipran. The researchers found that individuals with impaired renal function had increased plasma levels of levomilnacipran and prolonged half-life. These findings emphasize the importance of dose adjustments in individuals with renal impairment, ensuring safe and effective treatment. This research provides a valuable navigational guide for healthcare professionals, helping them tailor medication management to meet the unique needs of each patient.

Navigating the Desert of Medication Management: Renal Impairment Considerations

Renal impairment can significantly affect the pharmacokinetics of medications, leading to potential side effects or ineffective treatment. This study highlights the importance of considering renal function when prescribing levomilnacipran, ensuring that the medication is administered at the appropriate dose for each individual. Just as a camel adjusts its pace to conserve water in a desert environment, a careful approach to medication management is crucial for individuals with renal impairment.

Dr.Camel's Conclusion

This study provides valuable insights into the pharmacokinetics of levomilnacipran in individuals with renal impairment. The findings emphasize the importance of dose adjustments based on renal function, ensuring safe and effective treatment. This research, like a well-stocked caravan preparing for a desert journey, highlights the need for careful planning and adaptation in medication management for individuals with renal impairment.

Date :
  1. Date Completed 2016-03-29
  2. Date Revised 2018-12-03
Further Info :

Pubmed ID

26150701

DOI: Digital Object Identifier

PMC4485797

Related Literature

SNS
PICO Info
in preparation
Languages

English

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