Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation.

Author: SainiNeeru, SultanaSarwat, VarshneyPallavi, YadavJyoti, YadavVikas

Paper Details 
Original Abstract of the Article :
Pancreatic cancer, one of the most dreadful gastrointestinal tract malignancies, with the current chemotherapeutic drugs has posed a major impediment owing to poor prognosis and chemo-resistance thereby suggesting critical need for additional drugs as therapeutics in combating the situation. Fluoroq...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531397/

データ提供:米国国立医学図書館(NLM)

Fighting Pancreatic Cancer: A Multifaceted Approach

The battle against pancreatic cancer, one of the most aggressive and challenging forms of cancer, demands a relentless pursuit of innovative therapies. This study, like a desert explorer searching for a hidden oasis of cures, delves into the potential of combining existing drugs to enhance their effectiveness against this formidable foe. The researchers explored the synergy between fluoroquinolones, a class of antibiotics known for their anti-tumor properties, and cisplatin, a widely used chemotherapy agent, in combating pancreatic cancer cells. Their findings suggest that combining these drugs could provide a powerful new weapon in the fight against this deadly disease.

A Powerful Combination: Fluoroquinolones and Cisplatin

The study revealed that fluoroquinolones, such as moxifloxacin and ciprofloxacin, can augment the apoptotic effects of cisplatin in pancreatic cancer cells. It's like combining the strength of a desert sandstorm with the precision of a compass, creating a potent force against the cancer. The researchers identified the mechanism by which this synergy occurs, revealing a pathway that could be targeted for future drug development. Their findings offer a glimmer of hope for improving the treatment of pancreatic cancer, a disease that has long defied conventional therapies.

A New Frontier in Cancer Treatment: Synergy as a Weapon

This study highlights the potential of combining existing drugs to create more effective therapies, a strategy that's becoming increasingly important in the fight against cancer. It's like building a fortress of defense against a formidable enemy, using multiple layers of protection to maximize effectiveness. The researchers' findings underscore the need for further investigation into synergistic drug combinations, paving the way for a new era of cancer treatment.

Dr.Camel's Conclusion

This study offers a promising avenue for developing more effective treatments for pancreatic cancer. It's like uncovering a hidden oasis in the vast desert of cancer research, revealing a new strategy for combating this devastating disease. The researchers' findings underscore the potential of combining existing drugs to create more potent therapies, offering hope for a brighter future for those battling this formidable foe.

Date :
  1. Date Completed 2016-05-10
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26260159

DOI: Digital Object Identifier

PMC4531397

Related Literature

SNS
PICO Info
in preparation
Languages

English

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