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Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation.
Author: SainiNeeru, SultanaSarwat, VarshneyPallavi, YadavJyoti, YadavVikas
Original Abstract of the Article :
Pancreatic cancer, one of the most dreadful gastrointestinal tract malignancies, with the current chemotherapeutic drugs has posed a major impediment owing to poor prognosis and chemo-resistance thereby suggesting critical need for additional drugs as therapeutics in combating the situation. Fluoroq...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531397/
データ提供:米国国立医学図書館(NLM)
Fighting Pancreatic Cancer: A Multifaceted Approach
The battle against pancreatic cancer, one of the most aggressive and challenging forms of cancer, demands a relentless pursuit of innovative therapies. This study, like a desert explorer searching for a hidden oasis of cures, delves into the potential of combining existing drugs to enhance their effectiveness against this formidable foe. The researchers explored the synergy between fluoroquinolones, a class of antibiotics known for their anti-tumor properties, and cisplatin, a widely used chemotherapy agent, in combating pancreatic cancer cells. Their findings suggest that combining these drugs could provide a powerful new weapon in the fight against this deadly disease.
A Powerful Combination: Fluoroquinolones and Cisplatin
The study revealed that fluoroquinolones, such as moxifloxacin and ciprofloxacin, can augment the apoptotic effects of cisplatin in pancreatic cancer cells. It's like combining the strength of a desert sandstorm with the precision of a compass, creating a potent force against the cancer. The researchers identified the mechanism by which this synergy occurs, revealing a pathway that could be targeted for future drug development. Their findings offer a glimmer of hope for improving the treatment of pancreatic cancer, a disease that has long defied conventional therapies.
A New Frontier in Cancer Treatment: Synergy as a Weapon
This study highlights the potential of combining existing drugs to create more effective therapies, a strategy that's becoming increasingly important in the fight against cancer. It's like building a fortress of defense against a formidable enemy, using multiple layers of protection to maximize effectiveness. The researchers' findings underscore the need for further investigation into synergistic drug combinations, paving the way for a new era of cancer treatment.
Dr.Camel's Conclusion
This study offers a promising avenue for developing more effective treatments for pancreatic cancer. It's like uncovering a hidden oasis in the vast desert of cancer research, revealing a new strategy for combating this devastating disease. The researchers' findings underscore the potential of combining existing drugs to create more potent therapies, offering hope for a brighter future for those battling this formidable foe.
Date :
- Date Completed 2016-05-10
- Date Revised 2018-12-02
Further Info :
Related Literature
English
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