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Robust Vaccine Responses in Adult and Pediatric Cord Blood Transplantation Recipients Treated for Hematologic Malignancies.

Author: BarkerJuliet N, BhattValkal, DevlinSean, GiraltSergio, KernanNancy A, LauerEmily, LubinMarissa, McElrathCourtney, PapanicolaouGenovefa, PeralesMiguel A, PonceDoris M, PurtillDuncan, ScaradavouAndromachi, ShahGunjan L, ShahMonica, ShuneLeyla, YoungJames W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cord blood transplantation (CBT) recipients, including adults and those with prior graft-versus-host disease (GVHD), have similar vaccine response rates to adult donor allograft recipients. Vaccination in CBT recipients is recommended, as responses to tetanus, diphtheria, pertussis, Haemophilus influenzae, and polio were observed in children (86% to 100%) and adults (53% to 89%).
Paper Details　
Original Abstract of the Article :
Because cord blood (CB) lacks memory T and B cells and recent decreases in herd immunity to vaccine-preventable diseases in many developed countries have been documented, vaccine responses in CB transplantation (CBT) survivors are of great interest. We analyzed vaccine responses in double-unit CBT r...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/26271191

データ提供：米国国立医学図書館（NLM）

Vaccination in Cord Blood Transplantation Recipients: A Hope for Immunity

Cord blood transplantation (CBT) is a life-saving procedure for patients with hematologic malignancies. However, the lack of memory T and B cells in cord blood can compromise immune function. This study, published in Biology of Blood and Marrow Transplantation, investigates the vaccine responses in adult and pediatric CBT recipients. The authors analyzed vaccine responses in a cohort of CBT recipients, evaluating the effectiveness of different vaccine types.

Vaccine Responses in CBT Recipients

The study found that CBT recipients, despite their compromised immune systems, can still mount robust immune responses to various vaccines. The authors observed successful responses to protein-conjugated vaccines, including Prevnar 7 and 13, as well as tetanus, diphtheria, pertussis, Haemophilus influenzae, and polio vaccines. These findings provide reassurance that vaccination is a viable option for CBT recipients, helping to protect them from vaccine-preventable diseases.

Challenges and Future Directions

The study highlights the importance of timing vaccination appropriately, considering factors such as graft-versus-host disease (GVHD) and prior rituximab treatment. The researchers also identified the importance of CD4(+)CD45RA(+) and CD19(+) cell recovery in influencing vaccine responses. These findings provide valuable insights into the factors that affect vaccine efficacy in CBT recipients, paving the way for future research aimed at optimizing vaccination strategies for this population.

Dr. Camel's Conclusion

This study reminds us that even in the face of adversity, the human immune system can be remarkably resilient. Like a camel traversing a harsh desert, CBT recipients demonstrate an ability to adapt and respond to challenges. The findings of this study provide hope for these patients and highlight the importance of ongoing research to improve their health and well-being.

Date :
  1. Date Completed 2016-08-17
  2. Date Revised 2023-11-11
Further Info :

Pubmed ID

26271191

DOI: Digital Object Identifier

NIHMS732488

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English

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