Paper Details

  1. Home
  2. Paper Details

Neuromotor Adverse Effects in 342 Youth During 12 Weeks of Naturalistic Treatment With 5 Second-Generation Antipsychotics.

Author: Al-JadiriAseel, AzzoSally, CarbonMaren, CorrellChristoph U, KaneJohn M, KapoorSandeep, SaitoEma, SarkariaTania, SheridanEva

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

In youth, the rates of extrapyramidal side effects (EPS) associated with second-generation antipsychotics (SGAs) were similar to those reported in adults. EPS were lower for quetiapine and olanzapine.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Second-generation antipsychotic (SGA) effects in youth were monitored to quantify extrapyramidal side effects (EPS) and to identify risk profiles for treatment-emergent EPS. METHOD: Data were analyzed for the nonrandomized, prospective Second-generation Antipsychotic Treatment Indication...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/26299293

データ提供：米国国立医学図書館（NLM）

Monitoring Neuromotor Side Effects of Second-Generation Antipsychotics in Youth

Second-generation antipsychotics (SGAs) are widely used for treating a variety of mental health conditions in youth. However, these medications can sometimes cause neuromotor side effects. This study aimed to quantify the occurrence of extrapyramidal side effects (EPS) in youth taking SGAs and identify risk factors for their development.

EPS: A Complex Issue in Youth Mental Health Treatment

The study analyzed data from a large cohort of youth taking SGAs for various mental health conditions. The researchers found that a significant proportion of youth (15.2%) developed drug-induced parkinsonism, a type of EPS. SGA type, dose, age, and baseline functioning were all found to be associated with the development of drug-induced parkinsonism.

Navigating the Balance Between Benefits and Risks

While SGAs can provide significant relief for mental health conditions, it's important to be aware of their potential side effects. This study underscores the importance of careful monitoring for EPS in youth taking SGAs, particularly those at higher risk. Healthcare providers must weigh the potential benefits of these medications against the risks, making individualized treatment decisions that prioritize patient safety and well-being.

Dr.Camel's Conclusion

This study highlights the complex relationship between SGA use and EPS in youth. While SGAs can be effective treatments for mental health conditions, it's crucial to be aware of their potential side effects and to monitor for any adverse reactions. Just as a camel must navigate a challenging desert environment, healthcare providers must carefully consider the risks and benefits of medication for each patient.
Date :
  1. Date Completed 2016-11-01
  2. Date Revised 2023-07-27
Further Info :

Pubmed ID

26299293

DOI: Digital Object Identifier

NIHMS712234

Related Literature

Article Analysis
・Side Effects of ziprasidone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.