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Effects of primaquine and chloroquine on oxidative stress parameters in rats.
Author: AndradeVanessa M, Carvalho-SilvaMilena, DajoriAna Luiza, Dal-PizzolFelipe, FerreiraGabriela K, GalantLetícia S, GiovanellaFrancianne, GomesLara M, GonçalvesRenata C, LongarettiLuiza M, MichelsMonique, ScainiGiselli, StreckEmilio L, de PráSamira D T, de SouzaRenan P
Original Abstract of the Article :
Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7,...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1590/0001-3765201520140637
データ提供:米国国立医学図書館(NLM)
Antimalarial Drugs: A Potential Oasis in the Desert of Oxidative Stress
The fight against malaria is a global battle that often involves the use of antimalarial drugs. This study investigates the effects of two commonly used antimalarial drugs, primaquine and chloroquine, on oxidative stress parameters in rats. The research delves into the intricate relationship between these drugs and oxidative stress, seeking to uncover potential side effects and inform the development of safer treatment strategies.
Oxidative Stress: A Potential Side Effect of Antimalarial Drugs
The findings suggest that prolonged treatment with primaquine and chloroquine may cause DNA damage, indicating a potential for oxidative stress. This highlights the importance of carefully considering the duration and dosage of antimalarial medications. However, further research is needed to fully understand the implications of these findings for human health.
Navigating the Desert of Antimalarial Therapy
This study reminds us that the desert of antimalarial therapy is not without its potential pitfalls. While these drugs offer vital protection against malaria, it is crucial to be aware of potential side effects such as oxidative stress. Consulting a healthcare professional is essential for safe and effective treatment, ensuring the journey through this desert is as smooth as possible.
Dr.Camel's Conclusion
Antimalarial drugs are a beacon of hope in the fight against malaria. However, this study reminds us that the desert of antimalarial therapy presents potential challenges in the form of oxidative stress. Navigating this landscape requires a balance between treatment efficacy and potential side effects, guided by healthcare professionals. Remember, every journey through this desert is unique, requiring a personalized approach to care.
Date :
- Date Completed 2016-05-23
- Date Revised 2015-09-24
Further Info :
Related Literature
English
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