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[Effects of Garcinia Acid Combined with Daunorubicin on Expression of Pregnane X Receptor in Leukemia Cell Line K562/A02].

Author: CaiXiao-Hui, ChenBao-An, ChengJian, DaiLu, FuRong, GaoChong, GuoQing-Long, WangFei, XiaGuo-Hua, ZhangXiao-Ping, ZhuHan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study suggests that low-dose gambogic acid (GA) can down-regulate PXR gene transcription and protein expression in K562/A02 cells, enhancing cell growth inhibition and increasing the effect of chemotherapy.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To explore the expression of PXR (Pregnane X receptor) in several malignant hematological cell lines, and to investigate the reversal effect of Gambogic acid (GA) on multi-drug resistance (MDR) of K562/A02 cell line and its reversal mechanism. METHODS: Transcription of PXR was detected b...See full text at original site
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引用元：
https://doi.org/10.7534/j.issn.1009-2137.2015.04.009

データ提供：米国国立医学図書館（NLM）

[Effects of Garcinia Acid Combined with Daunorubicin on Expression of Pregnane X Receptor in Leukemia Cell Line K562/A02]

Cancer treatment often involves complex strategies to overcome drug resistance. This study investigates the effects of gambogic acid (GA), a natural compound, in combination with daunorubicin (DNR) on the expression of pregnane X receptor (PXR) in a drug-resistant leukemia cell line (K562/A02).

Overcoming Drug Resistance: A Quest for Effective Therapies

The study found that PXR expression was significantly higher in the drug-resistant K562/A02 cell line compared to other leukemia cell lines. Low-dose GA enhanced the cell growth inhibition rate of DNR, suggesting that GA may be able to overcome drug resistance. The authors discovered that GA downregulated PXR expression, potentially contributing to its reversal effect on drug resistance.

Targeting PXR: A New Frontier in Cancer Treatment

This study highlights the potential of targeting PXR as a strategy for overcoming drug resistance in leukemia. The findings suggest that GA, by downregulating PXR expression, can enhance the effectiveness of chemotherapy drugs. This research opens new avenues for developing more effective treatments for drug-resistant cancers.

Dr.Camel's Conclusion

This study provides valuable insights into the role of PXR in drug resistance and the potential of GA to overcome resistance in leukemia. The findings suggest that targeting PXR could be a promising strategy for enhancing the effectiveness of chemotherapy drugs. Further research is needed to fully explore the therapeutic potential of GA and its effects on PXR expression in various cancer types.
Date :
  1. Date Completed 2015-11-23
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26314425

DOI: Digital Object Identifier

10.7534/j.issn.1009-2137.2015.04.009

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・Effects of daunorubicin
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in preparation
Languages

Chinese

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