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Management of side effects of BCR/ABL-negative chronic myeloproliferative neoplasm therapies. Focus on anagrelide.

Author: AnteloMaría Luisa, Gonzalez PorrasJose Ramón, KerguelenAna, RayaJose María, de Las HerasNatalia

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Hydroxyurea is a first-line cytoreductive therapy for high-risk patients with polycythemia vera or essential thrombocythemia, but resistance or intolerance can occur in about 20-25% of patients. Anagrelide is the treatment of choice for such patients, and is generally well-tolerated, with manageable cardiac side effects.
Paper Details　
Original Abstract of the Article :
Although hydroxyurea is considered the first-line cytoreductive therapy in high-risk patients with polycythemia vera or essential thrombocythemia, approximately 20-25% of patients develop resistance or intolerance and they need an alternative therapy. Anagrelide is the treatment of choice in patient...See full text at original site
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引用元：
https://doi.org/10.1586/17474086.2015.1088779

データ提供：米国国立医学図書館（NLM）

Managing Side Effects of Chronic Myeloproliferative Neoplasm Therapies: A Focus on Anagrelide

In the vast desert of medical research, we often encounter challenging landscapes like the management of chronic myeloproliferative neoplasms (CMPNs). This study, akin to a camel caravan navigating a sandy expanse, explores the side effects of CMPN therapies, particularly focusing on the drug anagrelide. It's like a journey through the intricacies of these therapies, seeking to understand their impact on patients. The study highlights the importance of anagrelide as a valuable alternative treatment for patients with essential thrombocythemia who are resistant or intolerant to hydroxyurea, the usual first-line treatment. It's like having a backup oasis in the desert of treatment options.

Anagrelide: A Promising Oasis in the Desert of Treatment Options

The study emphasizes the generally good tolerability of anagrelide, even though there are concerns about cardiac side effects. These side effects are usually mild and manageable, like a mild desert wind that can be weathered with proper planning. This study's findings provide valuable insights into the management of CMPNs and the careful navigation of the potential side effects of anagrelide, offering a roadmap for clinicians to ensure patient well-being.

Navigating the Side Effects: A Guide for Patient Care

This study serves as a valuable guide for healthcare providers, helping them understand the side effects of anagrelide and manage them effectively. It's like having a compass and map in the vast desert of CMPN treatment, guiding us towards a better understanding of the nuances of this therapy.

Dr. Camel's Conclusion

In the ever-evolving landscape of medical research, we often encounter new challenges and discoveries. This study, like a beacon in the desert, illuminates the potential of anagrelide as a viable alternative therapy for patients with essential thrombocythemia. It also highlights the importance of careful monitoring for potential side effects, ensuring that patients are well-equipped to navigate this therapeutic journey.

Date :
  1. Date Completed 2016-08-26
  2. Date Revised 2016-11-26
Further Info :

Pubmed ID

26368319

DOI: Digital Object Identifier

10.1586/17474086.2015.1088779

Related Literature

Article Analysis
・Side Effects of anagrelide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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