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Base-Modified Nucleosides as Chemotherapeutic Agents: Past and Future.

Author: BorlandKayla M, BurkeMatthew P, LitoshVladislav A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Nucleoside and nucleobase antimetabolites are important in treating cancer and infections. Their close resemblance to natural analogs provides potency but also incurs severe side effects, especially in chemotherapy. This review discusses current antimetabolite drugs and explores approaches to nucleobase modifications for developing novel bioactive nucleoside analogs with improved therapeutic windows.
Paper Details　
Original Abstract of the Article :
Nucleoside and nucleobase antimetabolites have substantially impacted treatment of cancer and infections. Their close resemblance to natural analogs gives them the power to interfere with a variety of intracellular targets, which on one hand gives them high potency, but on the other hand incurs seve...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.2174/1568026615666150915111933

データ提供：米国国立医学図書館（NLM）

Base-Modified Nucleosides: A New Frontier in Cancer Therapy

Nucleoside and nucleobase antimetabolites have been instrumental in treating cancer and infections. However, their close resemblance to natural counterparts often leads to severe side effects. This research explores the potential of novel base-modified nucleosides to develop more effective and less toxic cancer therapies. The study delves into the mechanisms of action of existing antimetabolites and explores promising strategies for developing new nucleoside analogs with improved therapeutic profiles.

Beyond Conventional Chemotherapy: A New Era of Precision

The study emphasizes the importance of developing novel nucleoside analogs with improved therapeutic windows. The authors outline strategies for modifying nucleobases to create compounds that selectively target cancer cells while minimizing off-target toxicity. It's like finding a new path through the desert, a more precise and targeted approach to cancer treatment.

Cancer Treatment: A Quest for Precision and Safety

This study underscores the need for innovative approaches to cancer therapy, focusing on developing drugs with enhanced efficacy and reduced side effects. The exploration of base-modified nucleosides represents a promising avenue for achieving this goal. It's a journey towards a more refined and personalized approach to cancer treatment, ensuring greater precision and safety for patients.

Dr.Camel's Conclusion

This study delves into the exciting world of base-modified nucleosides, exploring their potential as novel cancer therapies. The research highlights the importance of developing targeted and less toxic treatments, paving the way for a more patient-centered and effective approach to cancer care. It's a quest for new oases in the desert of cancer treatment, offering hope for a brighter future for patients.
Date :
  1. Date Completed 2016-11-02
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

26369814

DOI: Digital Object Identifier

10.2174/1568026615666150915111933

SNS
PICO Info
in preparation
Languages

English

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